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Cognitive-motor interference during gait in patients with Multiple Sclerosis: a mixed methods Systematic Review

B Postigo-Alonso1, A Galvao-Carmona2, I Benítez3

  • 1Department of Psychology, Universidad Loyola Andalucía, Seville, Spain; Human Neuroscience Lab (HNL), Universidad Loyola Andalucía, Seville, Spain.

Neuroscience and Biobehavioral Reviews
|September 7, 2018
PubMed
Abstract

Insights

Cognitive-motor interference (CMI) is a key marker for daily impairment in Multiple Sclerosis (MS). Standardized dual tasks, like verbal fluency while walking, can effectively assess CMI in MS patients.

Area of Science:

  • Neurology
  • Rehabilitation Science
  • Human Movement Science

Background:

  • Cognitive-motor interference (CMI) is recognized as a significant indicator of functional limitations in Multiple Sclerosis (MS).
  • Existing research on CMI in MS is fragmented, necessitating a comprehensive synthesis of evidence.
  • This systematic review aims to identify specific variables influencing CMI assessment in MS patients.

Purpose of the Study:

  • To systematically review and synthesize existing evidence on cognitive-motor interference (CMI) in Multiple Sclerosis (MS).
  • To identify specific motor and cognitive variables that are sensitive and specific indicators of CMI in MS.
  • To determine the optimal conditions for assessing CMI as a marker of daily life impairment in MS.

Main Methods:

  • A systematic review utilizing a mixed-methods approach.
  • Analysis of studies investigating cognitive-motor interference in individuals with Multiple Sclerosis.
  • Identification and description of sensitive and specific motor and cognitive variables.

Main Results:

  • Multiple Sclerosis patients exhibit significant cognitive-motor interference.
  • Key motor variables for detecting CMI include velocity, cadence, and double support time, with double support being specific to MS.
  • Cognitive tasks like Alternate Alphabet and Serial Subtracting 7s were sensitive; Verbal Fluency was both sensitive and specific for CMI in MS.

Conclusions:

  • Cognitive-motor interference assessment in MS should incorporate standardized dual tasks, such as Verbal Fluency while walking.
  • Measuring double support time and its impact on cognitive performance is recommended.
  • The clinical utility of CMI for evaluating MS patients is discussed, highlighting its potential as a valuable assessment tool.
Keywords:
Cognitive impairmentCognitive-motor interferenceDual taskDual-task costMultiple sclerosis

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