Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Early signals in the mitogenic response.

E Rozengurt

    Science (New York, N.Y.)
    |October 10, 1986
    PubMed
    Summary

    Growth factors and peptides stimulate fibroblast proliferation. This study integrates early cellular signals to form a unified hypothesis for regulating fibroblast growth.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Protein Kinase D1 (PKD1) Signaling Induces Growth-Promoting Effects in Murine Enteroids.

    Cellular and molecular gastroenterology and hepatology·2020
    Same author

    Metformin Restrains Pancreatic Duodenal Homeobox-1 (PDX-1) Function by Inhibiting ERK Signaling in Pancreatic Ductal Adenocarcinoma.

    Current molecular medicine·2015
    Same author

    Everolimus inhibits anti-HLA I antibody-mediated endothelial cell signaling, migration and proliferation more potently than sirolimus.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2014
    Same author

    Blockade of p-selectin is sufficient to reduce MHC I antibody-elicited monocyte recruitment in vitro and in vivo.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2013
    Same author

    Stimulation of the neurokinin 3 receptor activates protein kinase C epsilon and protein kinase D in enteric neurons.

    American journal of physiology. Gastrointestinal and liver physiology·2008
    Same author

    CCK(B)/gastrin receptor mediates synergistic stimulation of DNA synthesis and cyclin D1, D3, and E expression in Swiss 3T3 cells.

    Journal of cellular physiology·2001

    Area of Science:

    • Cell Biology
    • Molecular Biology
    • Biochemistry

    Background:

    • Fibroblast proliferation is crucial for tissue repair and development.
    • Polypeptide growth factors and regulatory peptides are known mitogens.
    • Pharmacological agents can also influence fibroblast growth.

    Purpose of the Study:

    • To investigate the early signaling events induced by mitogenic agents in fibroblasts.
    • To integrate these early signals into a comprehensive hypothesis for fibroblast growth regulation.

    Main Methods:

    • Utilized cultured fibroblasts as a model system.
    • Examined signaling pathways in the membrane, cytosol, and nucleus.
    • Assessed the mitogenic effectiveness of various agents.

    Main Results:

    • Identified key early signaling events in response to growth factors, peptides, and pharmacological agents.
    • Demonstrated that these factors can act alone or synergistically.
    • Observed distinct signaling patterns across cellular compartments.

    Conclusions:

    • Proposed a unified hypothesis integrating early signals for fibroblast growth control.
    • Highlighted the complex interplay of extracellular factors in regulating fibroblast mitogenesis.
    • Provided a framework for understanding fibroblast proliferation mechanisms.

    Related Experiment Videos