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Co-prescribing of linezolid and serotonergic agents in a general hospital setting
C Clarke1, M Finnegan2, A M O'Dwyer3
11Central Mental Hospital,Dundrum,Dublin,Ireland.
Background:
Co-prescription of linezolid and serotonergic agents (SSRIs, SNRIs, NaSSA, TCAs) can lead to serotonin syndrome, this study seeks to identify prescribing practise of these agents.
Methods:
Study of all general hospital inpatients prescribed intravenous linezolid in a 3-month period, using drug charts and clinical notes.
Results:
Co-prescription occurred in 20% with SSRIs most frequently concurrently used. There were no cases of serotonin syndrome. There was no evidence in clinical notes of vigilance for potential interaction.
Conclusion:
Co-prescription is common; awareness of potentially serious interaction is not evident in current practice.
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