Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Distribution of transposable elements in prokaryotes.

S Sawyer, D Hartl

    Theoretical Population Biology
    |August 1, 1986
    PubMed
    Summary

    This study models transposable element (TE) copy number in prokaryotes, considering fitness costs and benefits. Models predict equilibrium distributions, with parameters estimated using Escherichia coli data.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    French consensus on management of head and neck cancer surgery during COVID-19 pandemic.

    European annals of otorhinolaryngology, head and neck diseases·2020
    Same author

    Locally unresectable differentiated thyroid cancer: outcomes and perspectives.

    Endocrine·2020
    Same author

    Thyroid cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up†.

    Annals of oncology : official journal of the European Society for Medical Oncology·2019
    Same author

    Tuberculosis among children, adolescents and young adults in the Philippines: a surveillance report.

    Western Pacific surveillance and response journal : WPSAR·2019
    Same author

    Rescue transtracheal jet ventilation during difficult intubation in patients with upper airway cancer.

    Anaesthesia, critical care & pain medicine·2017
    Same author

    Fungal Pathogens in CF Airways: Leave or Treat?

    Mycopathologia·2017

    Area of Science:

    • * Evolutionary biology
    • * Population genetics
    • * Molecular biology

    Background:

    • * Transposable elements (TEs) are mobile genetic sequences found in genomes.
    • * Their proliferation within host genomes can impact host fitness.
    • * Understanding TE dynamics is crucial for prokaryotic genome evolution.

    Purpose of the Study:

    • * To develop mathematical models for transposable element (TE) copy number distribution in prokaryotic hosts.
    • * To investigate the impact of TE replication, host infection, and fitness costs/benefits on TE dynamics.
    • * To estimate model parameters using empirical data from *Escherichia coli*.

    Main Methods:

    • * Development of mathematical models incorporating TE infection, transposition, and fitness effects.
    • * Analysis of equilibrium distributions of TE copy number under various model assumptions.
    • * Parameter estimation using insertion sequence data from natural isolates of *Escherichia coli*.

    Main Results:

    • * Models predict diverse equilibrium distributions for TE copy number, including classical types.
    • * Fitness reduction correlates with increased TE copy number in models without TE benefits.
    • * A model including potential TE-mediated selective advantages was also explored.

    Conclusions:

    • * Mathematical modeling provides insights into transposable element dynamics in prokaryotes.
    • * TE copy number distributions are influenced by factors like fitness costs and potential benefits.
    • * Empirical data from *Escherichia coli* can inform and validate these population genetic models.

    Related Experiment Videos