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Comparing HbA1C by POC and HPLC.

Sungeeta Agrawal1, Steven E Reinert2, Grayson L Baird3

  • 1Division of Pediatric Endocrinology, Tufts Medical Center/ Tufts University School of Medicine, Boston, MA.

Rhode Island Medical Journal (2013)
|September 8, 2018
PubMed
Summary
This summary is machine-generated.

Point-of-care Hemoglobin A1C (HbA1C) testing showed wide variation at levels ≥ 14%. Central HbA1C testing is recommended for accurate diabetes management and patient counseling when POC results are high.

Keywords:
HbA1CType 1diabetespediatricspoint-of-care

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Area of Science:

  • Pediatric Endocrinology
  • Clinical Chemistry
  • Diabetes Mellitus Management

Background:

  • Point-of-care (POC) Hemoglobin A1C (HbA1C) testing is crucial for monitoring glycemic control in diabetes.
  • Limited data exists comparing POC HbA1C with High-Performance Liquid Chromatography (HPLC) at high values (≥ 14%).

Purpose of the Study:

  • To compare POC HbA1C with HPLC in children with Type 1 Diabetes Mellitus (T1DM).
  • To determine the range of HPLC HbA1C values when POC HbA1C is ≥ 14%.
  • To characterize patients with high POC HbA1C results.

Main Methods:

  • Retrospective chart review of pediatric patients with T1DM.
  • Analysis of corresponding POC and HPLC HbA1C test results from 2007-2013.
  • Focus on patients with POC HbA1C ≥ 14%.

Main Results:

  • Seventy-two patients (ages 5-21) had paired POC and HPLC tests.
  • Nineteen patients (mean age 16.1 years) had POC HbA1C ≥ 14%.
  • Their mean HPLC HbA1C was 14.1% (range 11.1-16.3%), indicating significant variability.

Conclusions:

  • POC HbA1C results ≥ 14% exhibit considerable variation.
  • Routine central HbA1C testing is advised for values ≥ 14% for accurate patient management.
  • Monitoring HbA1C trends is vital for assessing treatment effectiveness and providing positive reinforcement.