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Related Concept Videos

Pharmaceutical Equivalents01:26

Pharmaceutical Equivalents

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As defined by regulatory standards, pharmaceutical equivalents require generic drug products to have identical dosage forms and chemically identical active pharmaceutical ingredients (APIs). They must adhere to compendial or applicable standards for potency, content uniformity, disintegration times, and dissolution rates. In the case of modified-release dosage forms, variations in drug content are permissible as long as the delivered amount remains consistent with the innovator drug product.
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Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence01:22

Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence

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Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...
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Hybridoma Technology01:31

Hybridoma Technology

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Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
Hybridoma Selection
Commonly used fusion techniques — electroporation,...
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Pharmaceutical Alternatives: Excipients and Impurities-Related Therapeutic Nonequivalence01:19

Pharmaceutical Alternatives: Excipients and Impurities-Related Therapeutic Nonequivalence

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Pharmaceutical products contain more than just the active drug; they also contain various excipients such as binders, solubilizers, stabilizers, preservatives, and other elements. In some cases, impurities or contaminants might be present. Traditionally, quality control in pharmaceuticals has primarily focused on the analysis of the active drug, often overlooking the impact of these additional components. The recent issue with heparin contamination by over-sulfated chondroitin sulfate, a...
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Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Health Information Technology and Healthcare Information System01:30

Health Information Technology and Healthcare Information System

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Health Information Technology (HIT)
Health Information Technology, commonly called HIT, integrates advanced information systems and technology in healthcare settings. Its primary functions include:
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Related Experiment Video

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Failure of Cleaning Verification in Pharmaceutical Industry Due to Uncleanliness of Stainless Steel Surface
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Superdisintegrants used in pharmaceutical technology.

Jan Gajdziok

    Ceska a Slovenska Farmacie : Casopis Ceske Farmaceuticke Spolecnosti a Slovenske Farmaceuticke Spolecnosti
    |September 8, 2018
    PubMed
    Summary

    Superdisintegrants enhance drug release from solid dosage forms more effectively than traditional disintegrants. This article reviews synthetic, semi-synthetic, and natural superdisintegrants used in pharmaceutical technology.

    Area of Science:

    • Pharmaceutical Technology
    • Materials Science

    Background:

    • Disintegrants are crucial excipients in solid dosage forms, facilitating drug release and bioavailability.
    • Efficient disintegration ensures the active pharmaceutical ingredient is accessible in the dissolution medium.
    • Multiple mechanisms contribute to disintegration, often acting in combination.

    Purpose of the Study:

    • To review synthetic, semi-synthetic, and natural superdisintegrants.
    • To highlight the advantages of superdisintegrants in pharmaceutical formulations.
    • To discuss the role of superdisintegrants in achieving efficient drug release.

    Main Methods:

    • Literature review of superdisintegrant types and applications.
    • Analysis of superdisintegrant mechanisms and properties.

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  • Discussion of their impact on processability and mechanical characteristics.

    • Main Results:

    • Superdisintegrants enable efficient disintegration at lower concentrations.
    • They offer improved performance without compromising tablet quality.
    • A range of synthetic, modified, and natural superdisintegrants are available.

    Conclusions:

    • Superdisintegrants represent an advancement in solid dosage form design.
    • Their use optimizes disintegration time and enhances bioavailability.
    • The article provides an overview of key superdisintegrant representatives in current use.