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Related Experiment Video

Updated: Feb 5, 2026

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Ibuprofen intercalation and release from different layered double hydroxides.

Elsie E Gaskell1, Tina Ha1, Ashley R Hamilton1

  • 1Liverpool John Moores University, School of Pharmacy & Biomolecular Sciences, Liverpool, L3 3AF, UK.

Therapeutic Delivery
|September 8, 2018
PubMed
Summary
This summary is machine-generated.

Layered double hydroxides (LDHs) with specific chemical compositions impact ibuprofen (IBU) intercalation and release. MgAl-LDH showed high crystallinity, and anion-exchange resulted in slower IBU release compared to coprecipitation.

Keywords:
LDHanionic exchangecoprecipitationdrug releaseibuprofenlayered double hydroxides

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Pharmaceutical Science

Background:

  • Layered double hydroxides (LDHs) possess tunable chemical compositions influencing their structural properties.
  • Intercalation of active pharmaceutical ingredients like ibuprofen (IBU) into LDHs can modify drug release profiles and therapeutic efficacy.

Purpose of the Study:

  • To investigate the impact of different LDH chemical compositions (MgAl-LDH, MgFe-LDH, NiAl-LDH, NiFe-LDH) on ibuprofen intercalation.
  • To evaluate the in vitro release kinetics of ibuprofen from LDHs prepared by coprecipitation and anionic-exchange methods.

Main Methods:

  • Synthesis and characterization of four distinct LDHs: MgAl-LDH, MgFe-LDH, NiAl-LDH, and NiFe-LDH.
  • Intercalation of ibuprofen (IBU) into LDHs using both coprecipitation and anionic-exchange techniques.
  • In vitro drug release studies monitored using spectroscopic and diffractometric methods (FTIR, XRD).

Main Results:

  • MgAl-LDH exhibited the highest crystallinity; cation substitution generally decreased LDH structural order.
  • Fourier-transform infrared spectroscopy and powder X-ray diffractometry confirmed successful IBU intercalation into MgAl-LDH and MgFe-LDH.
  • Anionic-exchange intercalation led to a slower, partial release of IBU compared to the coprecipitation method.

Conclusions:

  • The chemical composition of LDHs is a critical factor governing their crystallinity, the efficiency of ibuprofen intercalation, and the subsequent drug release kinetics.
  • The choice of intercalation method (coprecipitation vs. anionic-exchange) significantly influences the drug release profile, with anionic-exchange yielding slower release.