Related Experiment Video
Updated: Feb 5, 2026
05:08
Gathering Self-Initiated Rat Behavioral Data to Characterize Post-Stroke Deficits
Published on: March 15, 2024
1.6K
Investigating post-stroke fatigue: An individual participant data meta-analysis
Toby B Cumming1, Ai Beng Yeo2, Jodie Marquez2
1Florey Institute of Neuroscience and Mental Health, University of Melbourne, Australia; Centre of Research Excellence in Stroke Rehabilitation and Brain Recovery, Australia.
Journal of Psychosomatic Research
|September 8, 2018
Summary
Post-stroke fatigue is linked to female sex, depression, longer time since stroke, and disability. A non-linear relationship with age was identified, with fatigue peaking in mid-life and the oldest age groups.
Area of Science:
- Neurology
- Psychiatry
- Public Health
Background:
- Post-stroke fatigue prevalence varies significantly across studies, with unclear underlying reasons.
- Understanding fatigue is crucial for improving stroke survivor quality of life.
Purpose of the Study:
- To conduct an Individual Participant Data (IPD) meta-analysis to investigate post-stroke fatigue and its associated factors.
- To increase statistical power for identifying novel associations with post-stroke fatigue.
Main Methods:
- An IPD meta-analysis was performed using data from 12 studies (n=2102) that utilized the Fatigue Severity Scale (FSS).
- Linear regression analyses were conducted with FSS total score as the dependent variable, accounting for study clustering.
- Key variables included FSS score, age, sex, time post-stroke, depressive symptoms, stroke severity, disability, and stroke type.
Main Results:
- Higher fatigue levels were independently associated with female sex, depressive symptoms, longer time since stroke, and greater disability.
- A significant cubic relationship between fatigue and age was observed, with peaks in mid-life and among the oldest individuals.
- No linear association was found between fatigue and age.
Conclusions:
- IPD meta-analysis identified longer time since stroke and a non-linear age relationship as novel factors associated with post-stroke fatigue.
- Findings highlight the complex interplay of demographic, clinical, and temporal factors in post-stroke fatigue.
- Further research can leverage IPD to refine understanding and management of post-stroke fatigue.
Related Concept Videos
01:21Fatigue
842
Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
842
01:12Analysis of Population Pharmacokinetic Data
758
Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
758
01:30Impact of Individuals on Individuals
388
Human behavior is intricately shaped by social influences that arise from interactions with others in diverse contexts. These influences not only mold beliefs and attitudes but also drive the regulation of behaviors through both direct communication and observational learning. The study of these processes falls within the domain of social psychology, which seeks to understand how individuals are affected by and affect those around them.Mechanisms of Social InfluenceDirect social influence...
388
01:09Directing Effect of Substituents: meta-Directing Groups
6.0K
Substituents on the benzene ring that direct an incoming electrophile to undergo substitution at the meta position are called meta directors. All meta directors either have a positive charge on the atom directly bonded to the ring or a partial positive charge. These groups function by withdrawing electrons from the ring through inductive and resonance effects. Consider the carbocation intermediates formed upon the addition of an electrophile on nitrobenzene at the...
6.0K
01:13Overview of Microsoft Excel as a Data Analysis Tool
1.6K
Microsoft Excel is a cornerstone tool for data analysis and statistical operations, offering a wide array of functionalities to manage, analyze, and visualize data efficiently. Recognized for its versatility, Excel facilitates the performance of basic to complex statistical operations, serving as an indispensable asset for analysts, researchers, and students alike. Excel's significance in data analysis emanates from its spreadsheet environment, where data can be organized in rows and...
1.6K
01:24Muscle Recovery and Fatigue
4.2K
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
4.2K