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sP- and sE-selectin in stroke patients with metabolic disorders

Malgorzata Pawelczyk1, Andrzej Glabiński1, Beata Kaczorowska1

  • 1Department of Neurology and Stroke, Medical University of Lodz, Zeromskiego Str 113, 90-549 Lodz, Poland.

Neurologia I Neurochirurgia Polska
|September 8, 2018
PubMed

Insights

Metabolic disorders like hyperglycemia and hyperlipidemia increase vascular injury and platelet activation markers in acute ischemic stroke patients. These soluble E- and P-selectin levels indicate atherothrombotic risk.

Area of Science:

  • Cardiovascular Research
  • Metabolic Syndrome
  • Neuroscience

Background:

  • Platelet and endothelial cell activation are key in atherosclerosis and thrombosis.
  • Metabolic disorders contribute to cardiovascular and thrombotic diseases.

Purpose of the Study:

  • To investigate the link between metabolic disorders and markers of platelet activity and vascular injury in acute ischemic stroke patients.

Main Methods:

  • Studied 84 acute ischemic stroke patients in four subgroups based on lipid and glucose levels.
  • Included 21 healthy controls.
  • Measured serum soluble E-selectin (sE-selectin) and P-selectin (sP-selectin) using ELISA.

Main Results:

  • Elevated sE- and sP-selectin levels were observed in patients with hyperglycemia and hyperlipidemia compared to controls and normolipidemic/normoglycemic patients.
  • No additional effect of combined hyperlipidemia and hyperglycemia was found on these markers.
  • sE- and sP-selectin concentrations positively correlated with LDL, TC, and HbA1c levels in all stroke patients.

Conclusions:

  • Soluble E- and P-selectin serve as valuable blood markers for vascular injury and platelet activation.
  • These markers can help assess the atherothrombotic potential of hyperglycemia and hyperlipidemia in stroke patients.
Abstract

Keywords:
HyperglycemiaHyperlipidemiaIschemic strokeSoluble E-selectinSoluble P-selectin

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