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Is autophagy associated with diabetes mellitus and its complications? A review

Debalina Bhattacharya1,2, Mainak Mukhopadhyay3, Maitree Bhattacharyya1

  • 1Department of Biochemistry, University of Calcutta, Kolkata-700019.

EXCLI Journal
|September 8, 2018
PubMed

Insights

Autophagy, a cellular process, is crucial for managing diabetes mellitus (DM) and its complications. Understanding autophagy

Area of Science:

  • Endocrinology
  • Cellular Biology
  • Metabolic Disorders

Background:

  • Diabetes mellitus (DM) is a growing global health concern.
  • Cellular injury and metabolic dysregulation drive diabetic complications.
  • Autophagy is increasingly recognized for its role in DM pathogenesis.

Purpose of the Study:

  • To review the regulation of autophagy in diabetes.
  • To explore autophagy's role in diabetic complications.
  • To identify autophagy as a potential therapeutic target for DM.

Main Methods:

  • Literature review of recent studies on autophagy and diabetes.
  • Analysis of autophagy's function in pancreatic beta cells and insulin-target tissues.
  • Synthesis of current understanding of autophagy's involvement in DM.

Main Results:

  • Autophagy is vital for normal pancreatic beta cell function.
  • Autophagy regulates key insulin-target tissues (liver, muscle, adipose).
  • Dysregulated autophagy contributes to diabetic complications.

Conclusions:

  • Autophagy plays a critical role in diabetes mellitus.
  • Targeting autophagy presents a promising therapeutic strategy for diabetes treatment.
  • Further research into autophagy modulation is warranted for effective DM management.
Keywords:
T2DMautophagycardiomyopathynephropathyretinopathytype 2 diabetes mellitus

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