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Updated: Feb 5, 2026

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
Published on: March 8, 2022
Immune checkpoint inhibitors in melanoma
Adam J Cooper1,2,3,1,2,3, Matteo S Carlino1,2,3,4,1,2,3,4, Richard F Kefford1,2,3,4,5,1,2,3,4,5
1Crown Princess Mary Cancer Centre, Westmead Hospital, Sydney, NSW, Australia.
Abstract:
The potential to harness the power of the immune system and effectively treat patients with metastatic melanoma is finally being realized with the advent of immune checkpoint inhibitors. These new therapies herald a new era in the treatment of melanoma with the potential to produce very durable responses and possible cure for a subset of patients, though bring with them challenges including novel toxicities and nonconventional response patterns. This article reviews the currently available immune checkpoint inhibitors, potential biomarkers to predict response and promising investigational approaches including combination therapies.
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