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Injection of Syngeneic Murine Melanoma Cells to Determine Their Metastatic Potential in the Lungs
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Pembrolizumab in the management of metastatic melanoma

Lavinia Spain1, Eugenie Younger1, Emine Hatipoglu1

  • 1The Royal Marsden Hospital, Fulham Road, London, SW3 6JJ, UK.

Melanoma Management
|September 8, 2018
PubMed

Pembrolizumab is a humanized IgG4 anti-PD-1 antibody that plays a major role in the treatment of advanced melanoma. Through blockade of PD-1, it leads to an increase in effector T-cell activity in the tumor microenvironment. Clinical trial outcomes for pembrolizumab in addition to pharmacokinetics, pharmacodynamics and safety of the compound are discussed in this article. Phase I trials have demonstrated safety and efficacy of pembrolizumab in advanced, pretreated melanoma patients. When compared with chemotherapy in a Phase II trial of ipilimumab-refractory patients, those treated with pembrolizumab showed superior progression-free survival. In addition, in the pivotal Phase III trial pembrolizumab improved overall survival compared with ipilimumab in patients naive to immune checkpoint inhibition. Pembrolizumab is well tolerated and has a favorable safety profile. Common adverse events are fatigue, rash, itching and diarrhea. Less frequent immune-related adverse events include hypothyroidism, colitis, hepatitis and pneumonitis.

Keywords:
MK-3475anti-programmed death-receptor-1immune checkpoint inhibitorimmunotherapymetastatic melanomapembrolizumabresponsesafetysurvival

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