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Updated: Feb 5, 2026
07:10
Isolation of Histone from Sorghum Leaf Tissue for Top Down Mass Spectrometry Profiling of Potential Epigenetic Markers
Published on: March 4, 2021
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Epigenetic markers in melanoma.
Weimin Guo1, Ting Xu1, Jonathan J Lee1
1Program in Dermatopathology, Department of Pathology, Brigham & Women's Hospital, Harvard Medical School, 221 Longwood Ave. EBRC 401, Boston, MA 02115, USA.
Melanoma Management
|September 8, 2018
Summary
Epigenetic alterations in DNA methylation, histone modification, and noncoding RNAs are key to melanoma development. Understanding these epigenetic markers offers new diagnostic and therapeutic strategies for advanced melanoma.
Area of Science:
- Oncology
- Cancer Biology
- Epigenetics
Background:
- Melanoma is a deadly skin cancer with poor prognosis, even with current treatments.
- Targeted therapies and cancer immunology have improved outcomes but not for metastatic disease.
- Epigenetic mechanisms are increasingly recognized as crucial in melanoma development.
Purpose of the Study:
- To review recent advances in understanding epigenetic markers in melanoma.
- To highlight the diagnostic potential of epigenetic alterations.
- To explore novel therapeutic strategies targeting epigenetic pathways in advanced melanoma.
Main Methods:
- Literature review of recent studies on melanoma epigenetics.
- Analysis of DNA methylation, histone modifications, and noncoding RNA roles.
- Focus on diagnostic and therapeutic implications.
Main Results:
- Imbalances in DNA methylation/demethylation contribute to melanoma.
- Dysregulation of histone modification and chromatin remodeling are implicated.
- Altered noncoding RNA function affects melanoma pathogenesis.
Conclusions:
- Epigenetic markers are vital in melanoma tumorigenesis.
- These markers hold promise for early diagnosis and prognosis.
- Targeting epigenetic pathways presents novel therapeutic opportunities for melanoma.
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