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Updated: Feb 5, 2026

Analysis of Lymph Node Volume by Ultra-High-Frequency Ultrasound Imaging in the Braf/Pten Genetically Engineered Mouse Model of Melanoma
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Analysis of Lymph Node Volume by Ultra-High-Frequency Ultrasound Imaging in the Braf/Pten Genetically Engineered Mouse Model of Melanoma

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Biology and treatment of BRAF mutant metastatic melanoma

Benjamin Y Kong1,1, Matteo S Carlino1,2,3,1,2,3, Alexander M Menzies2,3,4,2,3,4

  • 1Crown Princess Mary Cancer Care Centre, Westmead, Sydney, NSW 2145, Australia.

Melanoma Management
|September 8, 2018
PubMed

Insights

BRAF inhibitors offer clinical benefit for metastatic melanoma. This review covers BRAF mutations, their oncogenic role, and treatment responses, including targeted therapies and immunotherapy sequencing.

Area of Science:

  • Oncology
  • Genetics
  • Dermatology

Background:

  • BRAF inhibitors represent a significant advancement in metastatic melanoma treatment.
  • Understanding BRAF mutations is crucial for effective therapeutic strategies.

Purpose of the Study:

  • To review the spectrum of BRAF mutations in melanoma.
  • To discuss their role in oncogenesis, clinicopathological associations, and treatment response.
  • To explore BRAF fusion genes and immunotherapy sequencing.

Main Methods:

  • Literature review of BRAF mutations in melanoma.
  • Analysis of oncogenesis, clinicopathological features, and treatment outcomes.
  • Discussion of targeted therapies and immunotherapy.

Main Results:

  • BRAF mutations are key drivers in melanoma development.
  • Specific mutations (V600E, V600K) exhibit distinct biological and clinical characteristics.
  • BRAF fusion genes and immunotherapy sequencing present evolving treatment landscapes.

Conclusions:

  • BRAF inhibitors are foundational for metastatic melanoma.
  • Personalized treatment approaches considering specific BRAF alterations are essential.
  • Integrating targeted therapies with immunotherapy optimizes patient outcomes.
Keywords:
BRAFBRAF fusion genesV600EV600Kdabrafenibmelanomamutationtrametinibvemurafenib

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