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Management of the cutaneous adverse effects of antimelanoma therapy

Rose Congwei Liu1,2,1,2, Germana Consuegra1,2,1,2, Pablo Fernández-Peñas1,2,1,2

  • 1Department of Dermatology, Westmead Hospital, Sydney 2145, Australia.

Melanoma Management
|September 8, 2018
PubMed

Insights

Targeted therapy and immunotherapy for advanced melanoma cause frequent skin side effects. Recognizing and managing these toxicities is crucial for patient quality of life and treatment continuation.

Area of Science:

  • Oncology
  • Dermatology
  • Pharmacology

Background:

  • Advanced melanoma management has been transformed by targeted therapy and immunotherapy.
  • Cutaneous toxicities are the most common adverse effects (AEs) associated with these novel melanoma treatments.

Purpose of the Study:

  • To discuss the incidence and clinical presentation of skin toxicities from novel melanoma therapies.
  • To provide treatment guidelines for managing these cutaneous AEs.

Main Methods:

  • Review of current literature on targeted therapy and immunotherapy for melanoma.
  • Analysis of reported cutaneous adverse events and their management strategies.

Main Results:

  • Cutaneous toxicities are frequent and can significantly impact patient morbidity and quality of life.
  • Early recognition and proactive management are essential to prevent treatment interruption.

Conclusions:

  • Effective management of skin toxicities is fundamental for patients undergoing advanced melanoma treatment.
  • Healthcare professionals require knowledge of these AEs for patient counseling and prophylaxis initiation.
Keywords:
B-raf inhibitorsadverse drug reactionsanti-CTLA-4anti-PD-1cutaneous adverse eventmetastatic melanomamitogen-activated protein kinase inhibitorskin (melanoma)targeted therapy

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