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Updated: Feb 5, 2026

Murine Model of Metastatic Liver Tumors in the Setting of Ischemia Reperfusion Injury
Published on: August 30, 2019
Liver transplantation for metastatic neuroendocrine tumors
Louise Barbier1,1, Cindy Neuzillet2,2, Safi Dokmak1,1
1Department of HPB Surgery & Liver Transplantation, Beaujon Hospital (Assistance Publique Hôpitaux de Paris), University Denis Diderot Paris 7, 100 Bd du Général Leclerc, 92110 Clichy, France.
Abstract:
Neuroendocrine tumors are a heterogeneous group of rare epithelial tumors. Most of them are metastatic at the time of initial diagnosis. Liver transplantation (LT) has been proposed in selected patients with diffuse liver involvement. Rationale for LT in this indication is based on the frequently indolent nature of neuroendocrine tumors, the propensity for liver-only metastasis and the high rate of intrahepatic recurrence after resection. However, indications for LT for neuroendocrine liver metastases remain controversial, and patient selection criteria is still a matter of debate. The aim of this review is to summarize data regarding LT for neuroendocrine liver metastases by answering frequently asked questions about this issue.
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