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Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
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Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

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A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
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Regulation of Hematopoietic Stem Cells01:01

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Multipotency of Hematopoietic Stem Cells01:19

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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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What is Cancer?02:12

What is Cancer?

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Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
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Generation of Subcutaneous and Intrahepatic Human Hepatocellular Carcinoma Xenografts in Immunodeficient Mice
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Hepatic stem cells and cancers: a pathologist's view.

Neil D Theise1

  • 1Departments of Pathology & Medicine (Division of Digestive Diseases), Mount Sinai Beth Israel Medical Center, First Avenue at 16th Street, New York, NY 10003, USA.

Hepatic Oncology
|September 8, 2018
PubMed
Summary
This summary is machine-generated.

Dr. Neil Theise

Keywords:
canals of Heringcancer stem cellscombined hepatocellularcholangiocarcinomahepatocellularcarcinomaliver stem cells

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Area of Science:

  • Hepatology
  • Pathology
  • Stem Cell Biology

Background:

  • Neil Theise, a diagnostic liver pathologist and stem cell researcher, has made significant contributions to understanding human liver microanatomy.
  • His early work focused on premalignant dysplastic nodules in chronic liver disease.

Purpose of the Study:

  • To revise understandings of human liver microanatomy.
  • To identify potential liver stem cell niches and the marrow-to-liver regeneration pathway.

Main Methods:

  • Research on premalignant dysplastic nodules in human chronic liver disease.
  • Investigation of human liver microanatomy and stem cell niches.
  • Exploration of the marrow-to-liver regeneration pathway.

Main Results:

  • Revised understandings of human liver microanatomy.
  • Identification of potential liver stem cell niches.
  • Elucidation of the marrow-to-liver regeneration pathway.
  • Pioneering work in multiorgan adult stem cell plasticity.

Conclusions:

  • The research has advanced the understanding of liver regeneration and stem cell biology.
  • Dr. Theise's work has implications for regenerative medicine and liver disease treatment.