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Exploring the Potential of Mesenchymal Stem Cell Sheet on The Development of Hepatocellular Carcinoma In Vivo
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Biomarker development for hepatocellular carcinoma early detection: current and future perspectives
Shreya Sengupta1, Neehar D Parikh1
1Department of Internal Medicine, Division of Gastroenterology & Hepatology, University of Michigan, Ann Arbor, MI 48109, USA.
Hepatic Oncology
|September 8, 2018
Summary
Developing new biomarkers for early hepatocellular carcinoma (HCC) detection is crucial. This review explores promising biomarkers and technologies to improve HCC surveillance and patient survival.
Area of Science:
- Hepatocellular carcinoma (HCC) research
- Biomarker discovery and validation
- Cancer surveillance technologies
Background:
- Current hepatocellular carcinoma (HCC) surveillance methods are insufficient for early detection, impacting patient survival rates.
- There is a critical need for effective biomarkers to improve early diagnosis of HCC.
- Biomarker discovery involves a rigorous, multi-phase process for clinical application.
Purpose of the Study:
- To review the essential phases of biomarker discovery for clinical implementation in HCC.
- To identify and discuss promising investigational biomarkers and their current discovery stages for HCC.
- To highlight novel technologies, including miRNA, metabolomics, and proteomics, for early HCC detection.
Main Methods:
- Literature review of biomarker discovery phases and technologies.
- Analysis of promising investigational biomarkers for HCC.
- Examination of emerging technologies such as miRNA, metabolomics, and proteomics.
- Assessment of ongoing validation efforts using longitudinal patient cohorts.
Main Results:
- The five phases of biomarker discovery are essential for clinical translation.
- Investigational biomarkers in miRNA, metabolomics, and proteomics show significant promise for early HCC detection.
- Longitudinal cohorts are being established for biomarker validation in patients with cirrhosis.
Conclusions:
- Biomarker-based strategies offer a potential paradigm shift for HCC surveillance.
- Effective early detection of HCC through biomarkers can significantly improve patient survival.
- Continued research and validation are necessary to implement biomarker-based HCC surveillance.
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