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Updated: Feb 5, 2026

Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial
Published on: September 29, 2015
Improving gingival zenith in a unilateral cleft patient using Platelet-Rich Fibrin (PRF)
Dr Madhumitha Natarajan1, Dr Bharath Rao K2
1Associate Professor, Department of Orthodontics, Manipal College of Dental Sciences(MCODS), Manipal University, Manipal, Karnataka, India.
Abstract:
This case evaluated the short term outcome of alveolar ridge augmentation in a unilateral alveolar cleft patient. A 22 year old female patient reported with gaps in her front teeth in 2011. Clinical examination revealed a repaired unilateral cleft of the hard palate (on left side) with a missing 21 and 22. Diagnosis was class II Subdivision with crossbite in 13 region. A non-extraction plan with a quad helix appliance, proximal stripping of lower anteriors. Canine substitution of 23 to replace 22 and prosthetic rehabilitation to replace 21. An alveolar ridge augmentation procedure using PRF (Platelet-rich fibrin) extracted from patient blood using a plasma centrifuge system. The success of grafted bone were evaluated radiologically at 6 months, 12 months postoperatively.
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