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Treating Pediatric Asthma According Guidelines.

Riccardina Tesse1, Giorgia Borrelli1, Giuseppina Mongelli1

  • 1Allergy, Immunology and Pediatric Pulmonology Unit, Ospedale Pediatrico Papa Giovanni XXIII, Bari, Italy.

Frontiers in Pediatrics
|September 8, 2018
PubMed
Summary
This summary is machine-generated.

Pediatric asthma management involves stepwise therapy based on severity and control. Treatment decisions for childhood asthma require critical evaluation of differing international guidelines and evidence-based approaches.

Keywords:
asthmaasthma managementchildrenguidelinespharmacology

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Area of Science:

  • Pediatric Pulmonology
  • Clinical Practice Guidelines
  • Asthma Management

Background:

  • Childhood asthma is a prevalent chronic airway inflammatory disorder.
  • Current asthma management guidelines present conflicting recommendations on definition and treatment.
  • Severe and difficult-to-treat asthma requires specialized guidelines.

Purpose of the Study:

  • To review conventional and novel pediatric asthma treatments based on international guidelines.
  • To highlight key aspects and differences in clinical recommendations for asthma management.
  • To inform critical decision-making in childhood asthma care.

Main Methods:

  • Comparative analysis of major international asthma guidelines (GINA, BTS/SIGN, NICE).
  • Review of consensus documents and guidelines on severe asthma (ERS/ATS).
  • Evaluation of evidence for various pharmacological and non-pharmacological interventions.

Main Results:

  • Stepwise, age-specific therapy is recommended based on clinical severity and control.
  • Beta-2 agonists, corticosteroids, and leukotriene modifiers are primary drug classes.
  • Omalizumab is a biological agent for specific IgE-mediated allergic asthma cases.
  • Limited evidence exists for methotrexate, macrolides, and antifungals in pediatric asthma.

Conclusions:

  • Asthma treatment decisions necessitate critical appraisal of differing international consensus documents.
  • Step-up or step-down therapy should be considered based on treatment response within 3 months.
  • Integrating evidence-based pharmacological and non-pharmacological approaches optimizes pediatric asthma care.