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Updated: Feb 5, 2026

Retropinacol/Cross-pinacol Coupling Reactions - A Catalytic Access to 1,2-Unsymmetrical Diols
Published on: April 4, 2014
Temperature-controlled sequential Suzuki-Miyaura reactions for preparing unsymmetrical terphenyls
Xinmin Li1, Chun Liu, Lei Wang
1State Key Laboratory of Fine Chemicals, Dalian University of Technology, Linggong Road 2, Dalian 116024, China. cliu@dlut.edu.cn.
Abstract:
A one-pot protocol of double Suzuki-Miyaura reactions has been developed for the synthesis of unsymmetrical terphenyls. In the absence of a ligand, potassium bromophenyltrifluoroborate reacts with arylboronic acid and then sequentially with a hetero/aryl bromide by controlling the reaction temperature, providing unsymmetrical p- and m-terphenyl compounds in moderate to good overall yields. This protocol provides a convenient and practical approach to unsymmetrical terphenyls under ligand-free and aerobic conditions.
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