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3D SASHA myocardial T1 mapping with high accuracy and improved precision
Giovanna Nordio1, Aurélien Bustin2, Markus Henningsson2
1School of Biomedical Engineering and Imaging Sciences, King's College London, 4th Floor, Lambeth Wing, St Thomas' Hospital, London, SE1 7EH, UK. giovanna.nordio@kcl.ac.uk.
Magma (New York, N.Y.)
|September 8, 2018
Summary
A new 3D denoising technique significantly improved the precision of free-breathing 3D saturation-recovery-based myocardial T1 mapping. This enhancement makes 3D SASHA T1 mapping comparable to 2D MOLLI while retaining its advantages.
Area of Science:
- Cardiovascular Magnetic Resonance Imaging
- Quantitative Myocardial Imaging
Background:
- Myocardial T1 mapping is crucial for assessing tissue characteristics.
- Existing 3D saturation-recovery single-shot acquisition (SASHA) T1 mapping offers whole-heart coverage but can be limited by precision.
- Improving the precision of 3D SASHA is essential for accurate clinical assessment.
Purpose of the Study:
- To enhance the precision of a free-breathing 3D SASHA myocardial T1 mapping sequence.
- To evaluate the efficacy of a post-processing 3D denoising technique for T1 mapping.
Main Methods:
- A 3D denoising technique incorporating multi-contrast Beltrami regularization was applied to native T1-weighted images before pixel-wise T1 fitting.
- T1 phantoms and 15 healthy subjects were scanned using 3D SASHA on a 1.5T MRI scanner.
- 2D modified Look-Locker inversion recovery (MOLLI) and inversion-recovery spin-echo sequence (IRSE) were used for comparison.
Main Results:
- The 3D denoising technique improved the precision of 3D SASHA T1 maps, making it statistically comparable to 2D MOLLI.
- Phantom studies showed good accuracy for 3D SASHA, with minimal underestimation compared to 2D MOLLI.
- In vivo studies demonstrated no statistical difference in precision between denoised 3D SASHA and 2D MOLLI.
Conclusions:
- A 3D Beltrami regularization-based denoising technique substantially improves the precision of 3D SASHA myocardial T1 mapping.
- The enhanced 3D SASHA T1 mapping achieves precision similar to 2D MOLLI.
- This method preserves the superior accuracy and whole-heart coverage benefits of 3D SASHA.
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