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Stereotactic Radiosurgery for Gynecologic Cancer
Published on: April 17, 2012
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Gamma knife radiosurgery for recurrent gliomas
Zjiwar H A Sadik1,2,3, Patrick E J Hanssens4, Jeroen B Verheul4,5
1Gamma Knife Center, Elisabeth-Tweesteden Hospital, Tilburg, The Netherlands. s_shibie@hotmail.com.
Journal of Neuro-Oncology
|September 8, 2018
Summary
Gamma knife radiosurgery (GKRS) offers a safe and effective salvage treatment for recurrent gliomas, improving survival rates with minimal patient burden. This study highlights its efficacy in local tumor control and overall patient outcomes.
Area of Science:
- Neurosurgery
- Radiation Oncology
- Oncology
Background:
- Recurrent gliomas pose a significant challenge in neuro-oncology.
- Gamma knife radiosurgery (GKRS) is emerging as a valuable salvage treatment option.
- Optimizing survival and tumor control while minimizing patient burden is crucial.
Purpose of the Study:
- To evaluate the efficacy of GKRS as a salvage treatment for recurrent gliomas.
- To analyze local tumor control (TC), clinical outcomes, and survival rates.
- To assess the safety and burden associated with GKRS in this patient population.
Main Methods:
- Retrospective analysis of prospectively collected data from 92 patients treated with GKRS for recurrent gliomas.
- Inclusion criteria: GKRS for glioma between 2002 and 2015, excluding initial treatments.
- Data collected on local tumor control, progression, distant lesions, progression-free survival (PFS), and overall survival (OS).
Main Results:
- Tumor control (TC) rates were 37% overall (50% in low-grade gliomas [LGGs], 27% in high-grade gliomas [HGGs]).
- Local progression (LP) rates were 46% overall (31% in LGGs, 58% in HGGs).
- Median PFS and OS were 10.5 and 34.4 months, respectively. For LGGs: PFS 50.1 months, OS 86.6 months. For HGGs: PFS 5.7 months, OS 12.8 months. No serious adverse events were reported.
Conclusions:
- GKRS is a safe and effective salvage treatment for recurrent gliomas.
- GKRS demonstrates potential for improving survival rates in glioma patients, including those with high-grade tumors.
- The treatment offers a low burden approach for patients with recurrent gliomas.
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