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Fundus Photography as a Convenient Tool to Study Microvascular Responses to Cardiovascular Disease Risk Factors in Epidemiological Studies

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A Case-control Study on the Risk Factors for Ischemic Colitis.

Tetsufumi Uchida, Masashi Matsushima¹, Yasushi Orihashi

¹Department of Internal Medicine (gastroenterology), Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan. mmatsush@tokai.ac.jp.

The Tokai Journal of Experimental and Clinical Medicine

|September 8, 2018

Summary

Risk factors for ischemic colitis (IC) differ between age groups. While hypertension is a common risk for all ages, younger patients show links to laxative/enema use, and older patients to abdominal surgery and COPD.

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Area of Science:

Gastroenterology
Internal Medicine
Epidemiology

Background:

Ischemic colitis (IC) is an acute intestinal inflammation, historically associated with the elderly and arteriosclerosis.
Recent reports indicate a rise in IC cases among younger individuals, necessitating a re-evaluation of risk factors.

Purpose of the Study:

To identify risk factors for ischemic colitis (IC) across all age groups.
To compare and contrast these risk factors between elderly and non-elderly patient populations.

Main Methods:

A case-control study involving 209 patients diagnosed with IC and 209 age- and sex-matched controls.
Data collected from December 2004 to March 2017 at Tokai University Hospital.
Multivariable conditional logistic regression analysis to identify significant risk factors.

Main Results:

Drinking, abdominal surgery, hypertension, and malignant diseases were identified as risk factors for IC in the overall cohort.
In non-elderly patients, hypertension and laxative/enema use were significant risk factors.
Elderly patients showed significant associations with abdominal surgery, hypertension, COPD, malignant disease, and antiplatelet drug use.

Conclusions:

Risk factors for ischemic colitis vary significantly between younger and elderly populations.
Hypertension emerges as a consistent risk factor across all age groups studied.