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The Nucleolus

The Nucleolus

The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...

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Nodular fasciitis, a forgotten entity.

Amalia Luna¹, Leisa Molinari¹, Luis A Bollea Garlatti¹

¹Department of Dermatology, Hospital Italiano de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina.

International Journal of Dermatology

|September 8, 2018

Summary

Nodular fasciitis, a benign tumor, can be mistaken for sarcoma due to its rapid growth and cellularity. Early recognition by dermatologists is crucial to prevent misdiagnosis and unnecessary treatments.

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Area of Science:

Dermatopathology
Oncology
Surgical Pathology

Background:

Nodular fasciitis is a benign, reactive soft tissue proliferation.
It presents as a rapidly growing, solitary tumor.
Histologically, it mimics malignant sarcomas due to high cellularity and mitotic activity.

Observation:

Four cases of nodular fasciitis are presented.
Literature review on nodular fasciitis is included.
Cases were initially misdiagnosed as various sarcomas, including dermatofibrosarcoma protuberans, atypical fibroxanthoma, and leiomyosarcoma.

Findings:

Nodular fasciitis is a significant differential diagnosis in soft tissue tumors.
Misdiagnosis can lead to inappropriate surgical interventions and patient anxiety.
Accurate histopathological evaluation is essential for correct diagnosis.

Implications:

Increased awareness among dermatologists is vital for prompt and accurate diagnosis.
Avoiding misdiagnosis prevents unnecessary morbidity associated with aggressive treatments.
Distinguishing nodular fasciitis from sarcoma ensures appropriate patient management and outcomes.