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Updated: Feb 5, 2026

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
Published on: September 8, 2015
Autoantibody against new gene expressed in prostate protein is traceable in prostate cancer patients
Monireh Mohsenzadegan1,2, Fatemeh Saebi1, Mehdi Yazdani3
1Cellular & Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.
Aim:
We assessed an autoantibody against new gene expressed in prostate (NGEP) protein for prostate cancer (PCa) that may better diagnosis and prognosis approaches in the patients with PCa.
Methods:
Autoantibodies against NGEP were measured in sera of PCa patients by ELISA.
Results:
The autoantibody against NGEP is present in a significantly higher proportion in the sera of PCa patients as compared with healthy controls (p < 0.001). An inverse significant correlation was found between seropositive patients and Gleason score (p < 0.05) and serum prostate-specific antigen (recombinant NGEP; p < 0.05).
Conclusion:
The data showed that measurement of autoantibody against NGEP as a novel prostate-specific antigen in sera can be used as a potential biomarker to discriminate well-differentiated PCa patients from normal subjects.
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