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Updated: Feb 5, 2026

Scalable Syntheses of Graphene Oxide and Reduced Graphene Oxide using Cascade Design Oxidation and Highly Basic Reduction Reactions
Published on: July 3, 2025
Synthesis of biologically-active reduced graphene oxide by using fucoidan as a multifunctional agent for combination
Seounghun Kang1, Yu Lim Hong2,3, Bon-Cheol Ku2
1Department of Chemistry, Seoul National University, Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.
Abstract:
A therapeutic reduced graphene oxide (RGO) is synthesized by using fucoidan (Fu) as the reducing and surface functionalizing agent. The synthesized Fu-RGO exhibits promising characteristics for therapeutic applications such as high dispersity in aqueous media, biocompatibility, selective cytotoxicity to cancer cells, high loading capacity of the anticancer drug, and photothermal conversion effect. Therefore, Fu-GO is successfully harnessed as a combinatorial cancer treatment platform through bio-functional (Fu), chemo (doxorubicin (Dox)) and photothermal (RGO with near-infrared irradiation) modalities.
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