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Related Concept Videos

Coordination Number and Geometry02:57

Coordination Number and Geometry

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For transition metal complexes, the coordination number determines the geometry around the central metal ion. Table 1 compares coordination numbers to molecular geometry. The most common structures of the complexes in coordination compounds are octahedral, tetrahedral, and square planar.
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Lattice Centering and Coordination Number02:33

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The structure of a crystalline solid, whether a metal or not, is best described by considering its simplest repeating unit, which is referred to as its unit cell. The unit cell consists of lattice points that represent the locations of atoms or ions. The entire structure then consists of this unit cell repeating in three dimensions. The three different types of unit cells present in the cubic lattice are illustrated in Figure 1.
Types of Unit Cells
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Non-Verbal Cues01:29

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Non-verbal communication extends beyond gestures and facial expressions to include vocal elements known as paralanguage. Paralanguage consists of non-verbal vocal cues such as pitch, loudness, speech rate, pauses, and non-verbal vocalizations like laughter, sighs, and moans. These elements not only accompany speech but also provide critical emotional and contextual information.The Role of Paralanguage in CommunicationParalanguage adds depth to spoken language by conveying emotions and...
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Coordination Compounds and Nomenclature02:54

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In most main group element compounds, the valence electrons of the isolated atoms combine to form chemical bonds that satisfy the octet rule. For instance, the four valence electrons of carbon overlap with electrons from four hydrogen atoms to form CH4. The one valence electron leaves sodium and adds to the seven valence electrons of chlorine to form the ionic formula unit NaCl (Figure 1a). Transition metals do not normally bond in this fashion. They primarily form coordinate covalent bonds, a...
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Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

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A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
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Cells Coordinate Growth and Proliferation02:36

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Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
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Related Experiment Video

Updated: Feb 5, 2026

Imaging of Cell Shape Alteration and Cell Movement in Drosophila Gastrulation Using DE-cadherin Reporter Transgenic Flies
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Cell shape alteration during adipogenesis is associated with coordinated matrix cues.

Lisa Mor-Yossef Moldovan1, Maayan Lustig2, Alex Naftaly1

  • 1Department of Cell and Developmental Biology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Journal of Cellular Physiology
|September 8, 2018
PubMed
Summary

This study quantifies adipogenesis, the development of fat tissue, using live cell imaging and proteomics. Researchers observed changes in cell shape, extracellular matrix, and cytoskeleton during fat cell differentiation, offering insights into obesity and related diseases.

Keywords:
ECM and cytoskeleton remodelingadipogenesiscell nichecollagensmass spectrometry

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Area of Science:

  • Cell Biology
  • Biochemistry
  • Metabolic Disease Research

Background:

  • Obesity is a major health concern linked to numerous pathophysiological disorders, including type 2 diabetes.
  • Adipose tissue plays a central role in obesity and its associated complications.
  • Understanding adipogenesis is crucial for developing strategies to combat obesity.

Purpose of the Study:

  • To quantify adipogenesis using in vitro live cell imaging and proteomic analysis.
  • To investigate the cellular and molecular changes during fat cell differentiation.
  • To explore the role of the extracellular matrix and cytoskeleton in adipogenesis.

Main Methods:

  • In vitro live cell imaging to monitor intracellular lipid droplet accumulation.
  • Nondestructive digital imaging to analyze cell morphology changes.
  • High-resolution mass spectrometry-based proteomics to identify molecular alterations.
  • Analysis of extracellular matrix and cytoskeleton remodeling during adipogenesis.

Main Results:

  • Quantified adipogenesis by monitoring lipid droplet accumulation and cell shape changes from fibroblast to spherical morphology.
  • Identified significant extracellular matrix reorganization from fibrillary collagens (I, III, V) to collagens IV and VI.
  • Observed cytoskeleton remodeling, with actin fiber rearrangement correlating with lipid droplet accumulation.

Conclusions:

  • Developing advanced in vitro models and analytical methods facilitates the study of adipogenesis.
  • Understanding niche conditions affecting adipogenesis can lead to new obesity prevention strategies.
  • This research provides a foundation for developing treatments for obesity-related pathophysiology.