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Related Concept Videos

Tissues01:18

Tissues

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Cells with similar structure and function are grouped into tissues. A group of tissues with a specialized function is called an organ. There are four main types of tissue in vertebrates: epithelial, connective, muscle, and nervous.
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Tissues01:25

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Tissues are a group of cells that share a common embryonic origin. Microscopic observation reveals that the cells in a tissue share morphological features and are arranged in an orderly pattern to perform specific functions. From an evolutionary perspective, tissues appear in more complex organisms. Although there are many types of cells in the human body, they are organized into four broad categories of tissues: epithelial, connective, muscle, and nervous. Each of these categories is...
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Tumor Immunotherapy01:27

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Tumor Progression02:07

Tumor Progression

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Plant Cells and Tissues02:01

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Plant tissues are collections of similar cells performing related functions. Different plant tissues will have their own specialized roles and can be combined with other tissues to form organs such as flowers, fruit, stem, and leaves. Two major types of plant tissue include meristematic and permanent tissue.
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Related Experiment Video

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Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
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Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

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Lipomatous Soft-tissue Tumors.

Christopher N Johnson1, Alice S Ha, Eleanor Chen

  • 1From the Parkview Cancer Institute (Dr. Johnson), Parkview Regional Medical Center, Ft. Wayne, IN, and the Department of Radiology (Dr. Ha), and the Department of Pathology (Dr. Chen), and the Department of Orthopedics and Sports Medicine (Dr. Davidson), University of Washington, Seattle, WA.

The Journal of the American Academy of Orthopaedic Surgeons
|September 8, 2018
PubMed
Summary
This summary is machine-generated.

Understanding magnetic resonance imaging (MRI) appearance is crucial for distinguishing benign lipomas from malignant liposarcomas. Proper MRI interpretation can prevent unnecessary surgeries for soft-tissue tumors.

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Isolating Stem Cells from Soft Musculoskeletal Tissues
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Area of Science:

  • Oncology
  • Radiology
  • Pathology

Background:

  • Lipomatous soft-tissue tumors are common, ranging from benign lipomas to high-grade liposarcomas.
  • Misdiagnosis of lipomas can lead to unplanned excisions of sarcomas.
  • Magnetic resonance imaging (MRI) is key to differentiating these tumors.

Purpose of the Study:

  • To highlight the diagnostic magnetic resonance imaging (MRI) appearance of lipomatous soft-tissue tumors.
  • To guide the appropriate use of MRI for soft-tissue masses.
  • To improve the management of potential sarcomas.

Main Methods:

  • Review of magnetic resonance imaging (MRI) characteristics of lipomatous soft-tissue tumors.
  • Guidelines for MRI acquisition of soft-tissue masses.
  • Correlation of imaging findings with tumor type and prognosis.

Main Results:

  • MRI is recommended for soft-tissue masses deep to fascia or >5 cm in subcutaneous tissue.
  • Atypical lipomatous tumors and well-differentiated liposarcomas present as large, deep fatty masses.
  • Lack of isointense signal to subcutaneous fat on MRI suggests sarcoma, requiring biopsy.

Conclusions:

  • Accurate interpretation of MRI can prevent unplanned excisions of sarcomas.
  • Large deep lipomatous masses and liposarcomas warrant referral to a sarcoma center.
  • Understanding MRI features is vital for appropriate patient management.