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Updated: Feb 5, 2026
08:48
Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
Published on: January 29, 2016
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Meta-analytic and Scoping Study on Strength Training in People With Multiple Sclerosis
Andrea Manca1, Zeevi Dvir2, Franca Deriu1
1Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
Journal of Strength and Conditioning Research
|September 8, 2018
Summary
Strength training significantly improves muscle strength and walking performance in people with multiple sclerosis (MS). This meta-analysis confirms resistance exercise benefits for MS patients, though more consistent study reporting is needed.
Area of Science:
- Neurology
- Exercise Physiology
- Rehabilitation Science
Background:
- Multiple Sclerosis (MS) is a chronic neurological disease affecting muscle strength and functional capacity.
- Resistance training is a potential intervention to mitigate these effects.
Purpose of the Study:
- To determine the pooled effect of strength training on muscle strength and functional capacity in people with MS (PwMS).
- To identify methodological strengths and limitations in existing research.
Main Methods:
- A meta-analysis and scoping study of randomized controlled trials.
- Searched five databases and two registries up to May 2017.
- Included 11 trials with 426 subjects, assessing study quality and risk of bias.
Main Results:
- Strength training increased muscle strength by 23.1% (p = 0.002) with a moderate effect size.
- Walking speed improved by 16.3% (p = 0.0002) and 2-minute walking test distance by 6.7% (p = 0.04).
Conclusions:
- People with MS demonstrate consistent strength gains in response to resistance training.
- While walking performance significantly improves, methodological inconsistencies limit a full understanding of functional capacity impacts.
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