Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lymphatic Vessels and Lymph Transport01:16

Lymphatic Vessels and Lymph Transport

23.3K
Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular...
23.3K
Patient-centered Care01:13

Patient-centered Care

3.1K
Patient-centered care involves delivering care beyond inpatient hospitalization. Reflective practice can enhance a patient-centered approach. Reflective practice is a process of reasoning that considers all aspects of the present situation, including practicalities, learning from personal practice, and consideration of patient needs. Patients appreciate care decisions made while considering their input. Involving the patient in their care provides the patient with a sense of contribution rather...
3.1K
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

278
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
278
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

268
In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
268
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

239
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
239
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

266
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
266

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intravenous Thrombolysis at Primary Stroke Centers Versus Comprehensive Stroke Centers: Analysis From the AcT Trial.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques·2026
Same author

Asundexian for Secondary Stroke Prevention.

The New England journal of medicine·2026
Same author

MRI measurement of the delayed secondary ischaemic injury following endovascular thrombectomy: results from the REPERFUSE-NA1 study.

European stroke journal·2026
Same author

Intracranial CTA-for-All Nontraumatic ICH.

Cerebrovascular diseases (Basel, Switzerland)·2026
Same author

Recombinant factor VIIa versus placebo for spontaneous intracerebral haemorrhage within 2 h of symptom onset (FASTEST): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial.

Lancet (London, England)·2026
Same author

Reperfusion grade and clinical outcome following medium vessel occlusion thrombectomy in the Endovascular Treatment to Improve Outcomes for Medium Vessel Occlusions (ESCAPE-MeVO) trial.

Journal of neurointerventional surgery·2026

Related Experiment Video

Updated: Feb 5, 2026

Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model
05:32

Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model

Published on: August 11, 2023

3.0K

Modeling Stroke Patient Transport for All Patients With Suspected Large-Vessel Occlusion.

Jessalyn K Holodinsky1,2, Tyler S Williamson1,3, Andrew M Demchuk2,4,5

  • 1Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

JAMA Neurology
|September 8, 2018
PubMed
Summary

Choosing the best stroke transport strategy depends on travel times and treatment speed. Regional centralization of endovascular therapy may improve outcomes for large-vessel occlusion stroke patients.

More Related Videos

Modeling Stroke in Mice - Middle Cerebral Artery Occlusion with the Filament Model
06:28

Modeling Stroke in Mice - Middle Cerebral Artery Occlusion with the Filament Model

Published on: January 6, 2011

94.3K
Two-vessel Occlusion Mouse Model of Cerebral Ischemia-reperfusion
07:34

Two-vessel Occlusion Mouse Model of Cerebral Ischemia-reperfusion

Published on: March 1, 2019

12.4K

Related Experiment Videos

Last Updated: Feb 5, 2026

Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model
05:32

Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model

Published on: August 11, 2023

3.0K
Modeling Stroke in Mice - Middle Cerebral Artery Occlusion with the Filament Model
06:28

Modeling Stroke in Mice - Middle Cerebral Artery Occlusion with the Filament Model

Published on: January 6, 2011

94.3K
Two-vessel Occlusion Mouse Model of Cerebral Ischemia-reperfusion
07:34

Two-vessel Occlusion Mouse Model of Cerebral Ischemia-reperfusion

Published on: March 1, 2019

12.4K

Area of Science:

  • Neurology
  • Interventional Radiology
  • Public Health

Background:

  • Ischemic stroke with large-vessel occlusion (LVO) requires timely treatment with alteplase and/or endovascular therapy.
  • Optimal prehospital triage and transport strategies are crucial for maximizing patient outcomes.

Purpose of the Study:

  • To identify the optimal prehospital triage and transport strategy (mothership vs. drip-and-ship) for patients with suspected LVO stroke.
  • To model the probability of excellent outcomes for different transport scenarios based on time-dependent treatment efficacy.

Main Methods:

  • A theoretical conditional probability modeling study using existing clinical trial data.
  • Modeled time-dependent efficacy of alteplase and endovascular therapy.
  • Assessed accuracy of LVO screening tools for both transport strategies.

Main Results:

  • Transport strategy effectiveness is influenced by travel time, treatment speed, and screening tool accuracy.
  • When centers are close (≤60 min apart) and treatment times optimal, both strategies yield similar outcomes.
  • Drip-and-ship is favored with longer travel times (>60 min) or if the mothership strategy misses the alteplase window; mothership superiority expands with faster thrombolysis center times and higher screening tool accuracy.

Conclusions:

  • Prehospital transport decision-making for LVO stroke can be modeled and dynamically adapted.
  • Findings suggest regional centralization of endovascular therapy for optimal population-level benefit.
  • Transport strategy superiority is context-specific, varying with treatment and transport times, and triage tools.