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[DEPENDENCE OF FUNCTIONAL PARAMETERS OF RAT SKELETAL MUSCLE CONTRACTION FROM LEVEL CIRCULATING TRIIODOTHYRONINE].

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    Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova
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    Thyroid hormone, specifically free triiodothyronine, significantly impacts skeletal muscle function, influencing contraction speed and latency. Its positive effects extend beyond normal physiological levels, revealing an extended hormone activity range.

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    Area of Science:

    • Endocrinology
    • Muscle Physiology
    • Skeletal Muscle Biology

    Background:

    • Thyroid hormones play a crucial role in regulating metabolism and physiological functions.
    • Skeletal muscle contractility is known to be influenced by thyroid status.
    • Understanding the precise relationship between thyroid hormones and muscle function is essential for diagnosing and treating related disorders.

    Purpose of the Study:

    • To investigate the relationship between circulating free triiodothyronine levels and the functional parameters of skeletal muscle contraction.
    • To quantify the contribution of thyroid hormones to skeletal muscle contractile function.
    • To explore the dose-response relationship of free triiodothyronine on muscle activity.

    Main Methods:

    • Experiments were conducted on white rats with varying thyroid statuses (thyroidectomy, euthyroidism, hyperthyroidism, thyrotoxicosis).
    • Functional parameters of the tibialis anterior muscle, including contraction latency, average, and maximum contraction speed, were measured in situ.
    • Quantitative analysis was performed to correlate muscle function indicators with circulating free triiodothyronine levels.

    Main Results:

    • Free triiodothyronine significantly influences tibialis anterior muscle contraction parameters, reducing latency and increasing contraction speed.
    • The "thyroid contribution" of free triiodothyronine was quantified: 15% for latency reduction, 12% for average contraction speed, and 8% for maximum contraction speed.
    • A wide range of triiodothyronine concentration showed enhanced muscle activity, extending beyond the physiological norm, indicating an "extended corridor of hormone activity" with 7 distinct functional zones.

    Conclusions:

    • Free triiodothyronine is a critical determinant of skeletal muscle contractile function.
    • The positive impact of triiodothyronine on muscle function persists at concentrations significantly exceeding physiological norms.
    • A detailed functional activity curve of free triiodothyronine was constructed, illustrating its complex effects across a broad concentration spectrum.