Personal Activity Intelligence and Mortality in Patients with Cardiovascular Disease: The HUNT Study
Sophie K Kieffer1, Nina Zisko1, Jeff S Coombes2
1K.G. Jebsen Center for Exercise in Medicine at the Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
Insights
Achieving a weekly Personal Activity Intelligence (PAI) score of 100 or more significantly lowers cardiovascular disease (CVD) and all-cause mortality risk in patients with CVD. This benefit persists even if current physical activity (PA) recommendations are not met.
Area of Science:
- Cardiology
- Preventive Medicine
- Health Monitoring
Background:
- Cardiovascular disease (CVD) remains a leading cause of mortality worldwide.
- Personalized metrics for physical activity (PA) can offer tailored health guidance.
- Understanding the impact of PA on mortality in existing CVD patients is crucial.
Purpose of the Study:
- To investigate the association between Personal Activity Intelligence (PAI) and all-cause and CVD mortality in patients with self-reported CVD.
- To determine if meeting contemporary PA recommendations modifies the association between PAI and mortality.
Main Methods:
- Utilized data from 3133 CVD patients (64% male, mean age 67.6 years) from the Nord-Trøndelag Health Study (1984-2015).
- Calculated weekly PAI scores and categorized participants into four groups (0, ≤50, 51-99, ≥100).
- Employed Cox proportional hazards regression models to assess mortality risk.
Main Results:
- Over a mean follow-up of 12.5 years, 2936 deaths occurred, including 1936 CVD deaths.
- Individuals with weekly PAI scores ≥100 had a 36% lower risk of CVD mortality and 24% lower risk of all-cause mortality compared to inactive individuals.
- These risk reductions were consistent regardless of adherence to current PA recommendations.
Conclusions:
- A weekly PAI score of at least 100 is linked to reduced CVD and all-cause mortality in individuals with CVD.
- The mortality benefits of achieving a PAI score of 100+ are independent of meeting current PA guidelines.
- PAI offers a valuable personalized approach to improving health outcomes in CVD patients.
Objective:
To test whether Personal Activity Intelligence (PAI), a personalized metric of physical activity (PA) tracking, is associated with all-cause and cardiovascular disease (CVD) mortality in patients with self-reported CVD and to determine whether these associations change depending on whether contemporary PA recommendations are met.
Patients And Methods:
A total of 3133 patients with CVD (mean [SD] age, 67.6 [10.3] years; 64% men) were followed from the date of participation in the Nord-Trøndelag Health Study (between January 1, 1984, and February 28, 1986) until the date of death or the end of follow-up (December 31, 2015). The participants' weekly PAI score was calculated and divided into 4 groups (PAI scores of 0, ≤50, 51-99, and ≥100). We used Cox proportional hazards regression models to estimate hazard ratios for CVD and all-cause mortality rates.
Results:
After mean follow-up of 12.5 years (39,157 person-years), there were 2936 deaths (94%), including 1936 CVD deaths. Participants with weekly PAI scores of 100 or greater had 36% (95% CI, 21%-48%) and 24% (95% CI, 10%-35%) lower risk of mortality from CVD and all causes, respectively, compared with the inactive group. Participants had similar risk reductions associated with their weekly PAI scores regardless of following contemporary PA recommendations or not.
Conclusion:
Obtaining a weekly PAI score of at least 100 was associated with lower mortality risk from CVD and all causes in individuals with CVD regardless of whether the current PA recommendations were met.
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