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Related Concept Videos

Contact Angle01:13

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Related Experiment Video

Updated: Feb 5, 2026

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
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Contact sensitization in children with atopic dermatitis.

D Ozceker1, F Haslak2, F Dilek3

  • 1Saglik Bilimleri University, Okmeydani Education and Resarch Hospital, Department of Pediatric, Allergy and Immunolgy, Istanbul, Turkey.

Allergologia Et Immunopathologia
|September 9, 2018
PubMed
Summary

Children with atopic dermatitis often develop skin sensitization. This study found 17% of children with atopic dermatitis had sensitization, with common allergens including nickel sulfate, methychloroisothiazolinone, and cocamidopropyl betaine.

Keywords:
Allergic contactAtopicDermatitisNickelPatch tests

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Area of Science:

  • Pediatric Dermatology
  • Allergology
  • Immunology

Background:

  • Atopic dermatitis is a prevalent childhood skin condition.
  • Children with atopic dermatitis exhibit impaired skin barrier function, increasing susceptibility to sensitization.
  • Cutaneous sensitization is a common complication in pediatric atopic dermatitis.

Purpose of the Study:

  • To determine the frequency of cutaneous sensitizations in children diagnosed with atopic dermatitis.
  • To identify the specific allergens most frequently responsible for causing sensitization in this patient group.

Main Methods:

  • The study included 112 children with atopic dermatitis (ages 1-18) and 39 healthy controls (ages 1-8).
  • Atopic dermatitis diagnosis and severity were assessed using established criteria (Hanifin and Rajka, Scoring of Atopic Dermatitis).
  • Allergen exposure was evaluated through skin prick tests for aeroallergens/food allergens and patch tests for cosmetic and standard series.

Main Results:

  • 17% of children with atopic dermatitis showed sensitization to cosmetic or standard allergens via patch testing; controls did not (p=0.001).
  • Neither atopy nor atopic dermatitis severity significantly predicted cutaneous sensitization.
  • The most frequent sensitizing agents were nickel sulfate and methychloroisothiazolinone (4.5% each) in the standard series, and cocamidopropyl betaine (12.5%) in the cosmetic series.

Conclusions:

  • Cutaneous sensitization is a significant concern in children with atopic dermatitis.
  • Allergic contact dermatitis should be considered in the differential diagnosis of children with atopic dermatitis.
  • Identifying common allergens is crucial for managing sensitization in pediatric atopic dermatitis.