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Related Concept Videos

Overview of Muscle Tissues01:25

Overview of Muscle Tissues

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The human body has three types of muscle tissue: skeletal, smooth, and cardiac. Each class has unique properties that enable them to perform specific functions. However, all muscle tissues share certain properties, including elasticity, contractility, and excitability. 
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Tissues01:18

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Non-ohmic Devices00:51

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Mnemonic devices are cognitive tools that facilitate memory retention by linking new information to familiar patterns or organizational strategies. These techniques are beneficial for remembering complex or lengthy sets of information by simplifying and structuring them in easily retrievable ways.
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Classification of Skeletal Muscle Fibers01:48

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Skeletal muscles continuously produce ATP to provide the energy that enables muscle contractions. Skeletal muscle fibers can be categorized into three types based on differences in their contraction speed and how they produce ATP, as well as physical differences related to these factors. Most human muscles contain all three muscle fiber types, albeit in varying proportions.
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The muscles of the eye are sophisticated structures that control eye movement and focus, allowing for the precise and rapid adjustments necessary for vision. The human eye is controlled by ten muscles — six extraocular muscles, three intraocular muscles, and one primary eyelid retractor muscle.
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Perfusable Vascular Network with a Tissue Model in a Microfluidic Device
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Microfluidic devices for disease modeling in muscle tissue.

Mollie M Smoak1, Hannah A Pearce1, Antonios G Mikos1

  • 1Department of Bioengineering, Rice University, Houston, TX 77030, USA.

Biomaterials
|September 9, 2018
PubMed
Summary

Microfluidic devices offer advanced muscle-on-a-chip models for studying muscular diseases. This technology enhances drug screening and understanding of disease pathology for conditions like muscular dystrophy.

Keywords:
Ex vivo systemMicrofluidicsMuscleMuscle-on-a-chipMyopathy

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Area of Science:

  • Biomedical Engineering
  • Tissue Engineering
  • Microfluidics

Background:

  • Microfluidic devices are advancing tissue engineering.
  • Sophisticated microfabrication enables complex ex vivo models.
  • Muscle-on-a-chip technology is a key drug screening platform for muscular diseases.

Purpose of the Study:

  • Review current knowledge gaps in muscular disease models.
  • Highlight microfluidic devices' potential in understanding disease.
  • Showcase microfluidics for high-throughput screening of therapeutics.

Main Methods:

  • Review of microfluidic applications in muscular disease research.
  • Analysis of muscle-on-a-chip systems for drug screening.
  • Discussion of microfabrication techniques for complex cell models.

Main Results:

  • Microfluidics enables real-time monitoring of multiple cell types.
  • Muscle-on-a-chip models improve drug screening for muscular diseases.
  • Identified knowledge gaps in current muscular disease models.

Conclusions:

  • Microfluidic devices are powerful tools for muscular disease research.
  • These systems facilitate better understanding of disease pathology.
  • Microfluidics offers a platform for high-throughput therapeutic screening.