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Related Concept Videos

CRISPR01:59

CRISPR

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Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
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CRISPR and crRNAs02:53

CRISPR and crRNAs

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Bacteria and archaea are susceptible to viral infections just like eukaryotes; therefore, they have developed a unique adaptive immune system to protect themselves. Clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) are present in more than 45% of known bacteria and 90% of known archaea.
The CRISPR-Cas system stores a copy of foreign DNA in the host genome and uses it to identify the foreign DNA upon reinfection. CRISPR-Cas has three different...
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Cancer-Critical Genes I: Proto-oncogenes01:33

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
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Hybridoma Technology01:31

Hybridoma Technology

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Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
Hybridoma Selection
Commonly used fusion techniques — electroporation,...
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Health Information Technology and Healthcare Information System01:30

Health Information Technology and Healthcare Information System

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Health Information Technology (HIT)
Health Information Technology, commonly called HIT, integrates advanced information systems and technology in healthcare settings. Its primary functions include:
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Specific Heat01:16

Specific Heat

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The specific heat capacity of a substance refers to the energy required to increase the temperature of one gram of that substance by one degree Celcius. Specific heat capacity is often represented in calories (cal), grams (g), and degrees Celsius (oC), but can also be expressed in joules (J), kilograms (kg), and Kelvin (K), among other units.
For example, increasing the temperature of one gram of water by 1°C requires one calorie of heat energy and can be written as 1 cal/g-°C, or...
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Ubiquitous and Tissue-specific RNA Targeting in Drosophila Melanogaster using CRISPR/CasRx
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Specific Targeting of Oncogenes Using CRISPR Technology.

Felix Oppel1, Matthias Schürmann1, Peter Goon2

  • 1Department of Otolaryngology, Head and Neck Surgery, Klinikum Bielefeld, Bielefeld, Germany.

Cancer Research
|September 9, 2018
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Summary
This summary is machine-generated.

CRISPR-Cas9 gene editing offers precise targeting for cancer therapy. This study develops strategies to target viral cancer drivers and oncogenes, aiming to improve cancer treatment outcomes.

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Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Despite advances in molecular biology tools like CRISPR-Cas9 for genetic modification, survival rates for malignant tumors remain largely unchanged.
  • Translating established laboratory research methods, such as CRISPR technology, into clinical practice could significantly improve patient prognosis for various cancers.

Purpose of the Study:

  • To investigate the potential of CRISPR-Cas9 technology as a future cancer therapy approach.
  • To develop strategies for the specific targeting of viral cancer drivers and oncogenes activated by mutation using CRISPR technology.

Main Methods:

  • Utilized CRISPR-Cas9 (clustered regularly-interspaced short palindromic repeats and CRISPR-associated protein 9) technology for precise genomic manipulation.
  • Developed strategies for specifically targeting viral cancer drivers and oncogenes activated by mutation.

Main Results:

  • The study presents novel strategies for applying CRISPR technology to target specific cancer-driving genetic elements.
  • The research lays the groundwork for evaluating the safety and efficacy of CRISPR-based cancer therapies.

Conclusions:

  • CRISPR-Cas9 technology holds promise for developing targeted cancer therapies by precisely manipulating genomic loci.
  • Further research is needed to demonstrate the suitability and safety of CRISPR technology for clinical cancer treatment, balancing genetic risks and benefits.