Related Experiment Video

Updated: Feb 5, 2026

Orthotopic Transplantation of Syngeneic Lung Adenocarcinoma Cells to Study PD-L1 Expression
06:03

Orthotopic Transplantation of Syngeneic Lung Adenocarcinoma Cells to Study PD-L1 Expression

Published on: January 19, 2019

18.3K

Radiological Features of IDO1+/PDL1+ Lung Adenocarcinoma: A Retrospective Single-institution Study

Kazuki Takada1, Gouji Toyokawa2, Tetsuzo Tagawa2

  • 1Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan k_takada@surg2.med.kyushu-u.ac.jp.

Anticancer Research
|September 9, 2018
PubMed
Abstract

Insights

Combination therapy targeting indoleamine 2,3-dioxygenase 1 (IDO1) and programmed cell death 1 (PD1)/programmed cell-death ligand 1 (PDL1) shows promise for lung cancer. IDO1/PDL1 co-expression in lung adenocarcinoma correlates with radiological invasiveness.

Area of Science:

  • Oncology
  • Immunology
  • Radiology

Background:

  • Combination immunotherapy targeting the programmed cell death 1 (PD1)/programmed cell-death ligand 1 (PDL1) pathway and indoleamine 2,3-dioxygenase 1 (IDO1) is a promising strategy for non-small-cell lung cancer.
  • Investigating the clinical and radiological features of primary lung adenocarcinoma with co-expression of IDO1 and PDL1 is crucial for optimizing treatment selection.

Purpose of the Study:

  • To investigate the clinical features of primary lung adenocarcinoma samples that are positive for both indoleamine 2,3-dioxygenase 1 (IDO1) and programmed cell death ligand 1 (PDL1).
  • To analyze the radiological characteristics associated with IDO1 and PDL1 co-expression in lung adenocarcinoma.

Main Methods:

  • Immunohistochemistry was used to evaluate IDO1 and PDL1 expression in 388 resected primary lung adenocarcinoma samples.
  • Radiological features of patients with IDO1+/PDL1+ lung adenocarcinoma were analyzed using imaging data.

Main Results:

  • Of 388 specimens, 109 (28.1%) showed co-expression of IDO1 and PDL1.
  • Multivariate analysis revealed significant associations between IDO1+/PDL1+ tumors and vascular convergence, absence of surrounding ground glass opacity, and a high consolidation/tumor ratio.
  • Patients with IDO1+/PDL1+ tumors exhibited significantly higher maximum standardized uptake values on 18F-fluorodeoxyglucose positron-emission tomography/computed tomography.

Conclusions:

  • IDO1 and PDL1 co-expression in lung adenocarcinoma is significantly related to radiological invasiveness and malignancy.
  • Identifying patients with IDO1+/PDL1+ tumors may aid in selecting candidates who are likely to benefit from combination immunotherapy targeting these pathways.
Keywords:
CTIDO1PDL1lung adenocarcinoma

More Related Videos

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

20.9K
Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma13:18

Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma

Published on: March 3, 2023

1.8K

Related Concept Videos

Lung Capacity01:47

Lung Capacity

The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
56.4K
Radiological Investigation I: X-ray and CT01:30

Radiological Investigation I: X-ray and CT

Radiological investigations, including X-rays and computed tomography (CT) scans, are critical for diagnosing and evaluating various medical conditions. These imaging techniques provide valuable insights into the body's internal structures, aiding in the detection of abnormalities, assessment of disease progression, and development of treatment strategies. This article delves into two primary radiological investigations, chest X-rays and CT scans, outlining their purpose, procedures, and...
1.2K
Bioavailability Study Design: Single Versus Multiple Dose Studies01:11

Bioavailability Study Design: Single Versus Multiple Dose Studies

Bioavailability studies are essential for understanding how a drug is absorbed, distributed, metabolized, and excreted in the body. These studies assess the extent and rate at which the active pharmaceutical agent becomes available at the site of action. The design of bioavailability studies can involve single-dose or multiple-dose regimens, each with distinct advantages and limitations.Single-dose studies are the preferred approach due to their simplicity and reduced drug exposure for...
246
Radiological Investigation II: MRI and Ventilation Perfusion Scan01:30

Radiological Investigation II: MRI and Ventilation Perfusion Scan

Description
Magnetic Resonance Imaging (MRI) and Ventilation Perfusion Scans are two radiological investigations that offer detailed diagnostic images of the body, particularly lung structures.
MRI
MRI uses magnetic fields and radiofrequency signals to distinguish between normal and abnormal tissues. This technology provides a more detailed diagnostic image than CT scans, enabling it to characterize pulmonary nodules, stage bronchogenic carcinoma, and evaluate inflammatory activity in...
617
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.9K
Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
473