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Characterisation and functional predictions of canine long non-coding RNAs.

Céline Le Béguec1, Valentin Wucher1,2,3, Lætitia Lagoutte1,4

  • 1Univ Rennes, CNRS, IGDR (Institut de génétique et développement de Rennes) - UMR 6290, F-35000, Rennes, France.

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Researchers profiled over 10,000 long non-coding RNAs (lncRNAs) in dogs, finding many are tissue-specific and conserved across species. This study provides a key resource for understanding canine biology and disease.

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Area of Science:

  • Genomics
  • Transcriptomics
  • Molecular Biology

Background:

  • Long non-coding RNAs (lncRNAs) are crucial regulators in biological processes.
  • Predicting the function of the canine lncRNA repertoire is challenging.
  • Over 10,000 lncRNAs have been identified in domestic dogs.

Purpose of the Study:

  • To characterize the expression profiles of 10,444 canine lncRNAs across 26 tissue types.
  • To investigate the tissue-specificity and evolutionary conservation of canine lncRNAs.
  • To explore the functional roles of lncRNAs through co-expression analysis with protein-coding genes.

Main Methods:

  • Comprehensive transcriptomic profiling of 10,444 canine lncRNAs in 26 distinct tissues.
  • Comparative transcriptomics to identify conserved dog-human lncRNAs.
  • Co-expression network analysis to infer lncRNA regulatory functions.

Main Results:

  • Canine lncRNA expression is predominantly clustered by tissue type, with 44% exhibiting tissue-specific expression.
  • Tissue-specificity of lncRNAs correlates with specific transposable element families.
  • Over 900 dog-human conserved lncRNAs show reproducible expression patterns.
  • Co-expression analysis identified over 3,400 lncRNAs potentially acting as regulatory elements.

Conclusions:

  • This study presents a comprehensive genomic and transcriptomic resource for canine lncRNAs.
  • Findings highlight the significant tissue-specificity and evolutionary conservation of canine lncRNAs.
  • The identified lncRNAs offer insights into genotype-phenotype relationships and canine biomedical research.