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Notch in skeletal physiology and disease.

E Canalis1

  • 1Departments of Orthopaedic Surgery and Medicine, UConn Musculoskeletal Institute, UConn Health, 263 Farmington Avenue, Farmington, CT, 06030-4037, USA. canalis@uchc.edu.

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
|September 9, 2018
PubMed
Summary

The Notch signaling pathway regulates bone health and skeletal development. Understanding Notch signaling is crucial for treating skeletal disorders and bone diseases.

Keywords:
Congenital disordersJaggedNotchOsteoblastOsteoclast

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Area of Science:

  • Cell Biology
  • Developmental Biology
  • Biochemistry

Background:

  • Notch receptors (Notch1-4) and ligands (Jagged, Delta-like) are key in cell communication.
  • Notch signaling is vital for osteoblast and osteoclast function, impacting skeletal development and bone remodeling.

Purpose of the Study:

  • To review the role of Notch signaling in skeletal homeostasis and disease.
  • To highlight Notch signaling's involvement in bone cell differentiation, fracture healing, and congenital skeletal disorders.

Main Methods:

  • Literature review of studies on Notch signaling in skeletal biology.
  • Analysis of genetic mutations and their skeletal manifestations.
  • Examination of Notch signaling's role in bone-related diseases like osteosarcoma and metastasis.

Main Results:

  • Notch signaling critically influences osteoblast and osteoclast lineages and bone remodeling.
  • Mutations in Notch pathway components cause craniofacial and skeletal abnormalities.
  • Notch ligand Jag1 affects bone mineral density, and Notch aids fracture healing.

Conclusions:

  • Notch signaling is a significant regulator of skeletal homeostasis in both health and disease.
  • Targeting Notch signaling may offer therapeutic potential for skeletal disorders and related conditions.
  • Further clinical research is needed for agents modifying Notch signaling.