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Updated: Feb 5, 2026
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Systematic Assessment of Mammalian Skull Specimens for Dental and Temporomandibular Joint Pathology
Published on: August 22, 2022
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Interventions for dental fluorosis: A systematic review
Tamara Di Giovanni1, Theodore Eliades1, Spyridon N Papageorgiou1
1Clinic of Orthodontics and Pediatric Dentistry, Center of Dental Medicine, University of Zurich, Zurich, Switzerland.
Summary
Resin infiltration offers the most promising esthetic improvement for dental fluorosis, outperforming bleaching and microabrasion. This systematic review highlights resin infiltration as the leading treatment for fluorosed enamel, enhancing patient quality of life.
Area of Science:
- Dental Science
- Esthetic Dentistry
- Regenerative Medicine
Background:
- Dental fluorosis significantly impacts patients' quality of life.
- Effective esthetic rehabilitation treatments for dental fluorosis are crucial.
Purpose of the Study:
- To compare the effectiveness of different interventions for treating dental fluorosis.
- To identify the optimal treatment for esthetic rehabilitation of fluorosed enamel.
Main Methods:
- Systematic review of randomized clinical trials.
- Searched nine databases from inception to December 2016.
- Assessed risk of bias and used GRADE approach for evidence quality.
Main Results:
- Six trials involving 348 patients were included.
- Resin infiltration showed greater esthetic improvement than bleaching (moderate quality evidence).
- Microabrasion yielded less esthetic improvement compared to bleaching (low quality evidence).
Conclusions:
- Resin infiltration appears to be the most effective treatment for dental fluorosis.
- Bleaching and microabrasion are less effective alternatives.
- Further research is warranted due to limitations in current evidence.
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