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Inflammatory myopathies after allogeneic stem cell transplantation.
Julia New-Tolley1, Caroline Smith2, Barbara Koszyca2
1University of Adelaide, North Terrace, Adelaide, South Australia, 5000, Australia.
Muscle & Nerve
|September 9, 2018
Summary
Inflammatory myopathy (IM) can occur after allogeneic stem cell transplantation (allo-SCT). This study found an increased incidence of IM, with varied causes including chronic GVHD, necrotizing myopathy, and anti-MDA5 dermatomyositis.
Area of Science:
- Neurology
- Immunology
- Hematology
Background:
- Graft-versus-host disease (GVHD) is a known complication of allogeneic stem cell transplantation (allo-SCT).
- Muscle involvement can occur in patients undergoing allo-SCT, leading to inflammatory myopathy (IM).
Purpose of the Study:
- To investigate the incidence and subtypes of inflammatory myopathy (IM) in South Australian recipients of allo-SCT.
- To characterize the clinical and histopathological features of IM in this patient population.
Main Methods:
- Retrospective review of allo-SCT recipients from 2004-2014 at Royal Adelaide Hospital.
- Identification of patients with weakness, elevated creatine kinase (CK), and biopsy-confirmed IM.
Main Results:
- Weakness was observed in 32 of 224 (14.3%) allo-SCT recipients.
- Six patients were diagnosed with biopsy-confirmed IM.
- Diagnoses included chronic GVHD-related myopathy (3), necrotizing myopathy (2), and anti-MDA5 dermatomyositis (1).
- The annual incidence of IM was 2 cases per thousand.
Conclusions:
- The incidence of IM is increased in allo-SCT recipients.
- IM in this population presents with diverse histopathological findings.
- Necrotizing myopathy and anti-MDA5-associated dermatomyositis are notable subtypes.
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