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Link between depression and cardiovascular diseases due to epigenomics and proteomics: Focus on energy metabolism

Kai G Kahl1, Britta Stapel1, Helge Frieling1

  • 1Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Germany.

Progress in Neuro-Psychopharmacology & Biological Psychiatry
|September 9, 2018
PubMed

Insights

Major depression increases cardiovascular disease risk, sharing pathways like lifestyle and inflammation. Recent research highlights epigenomic and proteomic factors, especially mitochondrial energy metabolism, in this link.

Area of Science:

  • Neuroscience
  • Cardiology
  • Genetics

Background:

  • Major depression is a leading cause of disability and premature mortality.
  • Individuals with major depression face increased cardiovascular disease (CVD) risk.
  • A bi-directional relationship exists between major depression and CVD, suggesting shared underlying mechanisms.

Purpose of the Study:

  • To review the shared pathophysiological pathways between major depression and cardiovascular diseases.
  • To focus on the role of epigenomic and proteomic factors, particularly mitochondrial energy metabolism.

Main Methods:

  • Literature review of studies investigating the link between major depression and CVD.
  • Analysis of shared risk factors including lifestyle, endocrine, and inflammatory pathways.
  • Examination of recent research on epigenomic and proteomic influences.

Main Results:

  • Shared pathways include lifestyle factors (physical activity, smoking), endocrine system dysfunctions (hypothalamus-pituitary adrenal axis), and inflammatory imbalances.
  • Emerging evidence implicates epigenomic and proteomic factors in the depression-CVD link.
  • Mitochondrial energy metabolism is a key area of focus in recent research.

Conclusions:

  • Understanding shared pathways is crucial for managing both major depression and cardiovascular diseases.
  • Epigenomic and proteomic factors, especially related to mitochondrial function, represent promising targets for future research and intervention.

Keywords:
Cardiovascular diseasesEnergy metabolismEpigenomicsMajor depressionProteomics

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