Long non-coding RNAs in coronary atherosclerosis

Area of Science:

• Cardiovascular Biology
• Molecular Medicine
• Atherosclerosis Research

Background:

• Coronary atherosclerosis (CAS) is a primary cause of global mortality, characterized by complex pathogenesis involving dyslipidemia, metabolic dysfunction, and inflammation.
• Endothelial cell (EC) injury and subsequent inflammatory responses are key initiating factors in CAS development.
• The intricate mechanisms underlying CAS necessitate research into vascular cell dysfunction, metabolic disorders, and immune responses.

Purpose of the Study:

• To review the significant role of non-coding RNAs, particularly long non-coding RNAs (lncRNAs), in the pathogenesis of coronary atherosclerosis (CAS).
• To explore the regulatory functions of lncRNAs in the progression of CAS.
• To discuss the potential of lncRNAs in the prevention and treatment strategies for CAS.

Main Methods:

• Literature review focusing on non-coding RNAs and their involvement in cardiovascular disease.
• Analysis of current research on lncRNA functions in the context of CAS pathogenesis.
• Synthesis of findings related to lncRNA mechanisms in endothelial dysfunction, lipid metabolism, and inflammatory pathways.

Main Results:

• lncRNAs are increasingly recognized as critical regulators in the complex pathogenesis of CAS.
• Specific lncRNAs influence key processes such as EC injury, VSMC proliferation, and inflammatory signaling in CAS.
• Dysregulation of lncRNAs contributes to the development and progression of coronary atherosclerosis.

Conclusions:

• lncRNAs represent a promising area for understanding CAS mechanisms.
• Targeting lncRNAs may offer novel therapeutic avenues for preventing and treating coronary atherosclerosis.
• Further investigation into lncRNA functions is essential for advancing cardiovascular disease management.