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Locomotor Training Promotes Time-dependent Functional Recovery after Experimental Spinal Cord Contusion.

M R Marques1, F C Nicola2, E F Sanches3

  • 1Post-Graduation Program of Neurosciences, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Área de Conhecimento de Ciências da Vida, Universidade de Caxias do Sul, Caxias do Sul, RS, Brazil; Cerebral Ischemia and Neuroprotection Laboratotory, Biochemistry Department, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.

Neuroscience
|September 9, 2018
PubMed
Summary
This summary is machine-generated.

Starting locomotor training (LT) later after spinal cord injury (SCI) improves functional recovery. Early LT initiation worsened outcomes, highlighting a critical therapeutic window for rehabilitation.

Keywords:
locomotor impairmentneuroprotectionspinal cord injury (SCI)therapeutic windowtissue protectiontreadmill training

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Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Rehabilitation Science

Background:

  • Locomotor training (LT) is studied for spinal cord injury (SCI) treatment, but outcomes vary.
  • The timing of LT initiation post-SCI is a critical factor influencing functional recovery.

Purpose of the Study:

  • To determine the optimal timing for initiating LT after SCI in a rat model.
  • To investigate the effects of early versus late LT on motor function and spinal cord/muscle morphology.

Main Methods:

  • Wistar rats with spinal cord contusion received LT starting 7, 14, or 28 days post-injury.
  • Motor function was assessed using BBB scale and Horizontal Ladder test.
  • Spinal cord and muscle tissues underwent morphological and biochemical analysis.

Main Results:

  • Late LT initiation (14 and 28 days) improved motor function and preserved motoneurons.
  • Early LT (7 days) worsened functional performance and increased lesion volume.
  • Late training enhanced muscle fiber area and BDNF expression in the tibialis anterior.

Conclusions:

  • The timing of LT initiation significantly impacts functional recovery after SCI.
  • Initiating LT 14 or 28 days post-injury is beneficial, while 7-day initiation is detrimental.
  • These findings define a critical therapeutic window for LT in SCI rehabilitation.