Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

NMR Spectroscopy Of Amines01:19

NMR Spectroscopy Of Amines

11.1K
In proton NMR spectroscopy, primary amines and secondary amines showcase their N–H protons as a broad signal in the chemical shift range between δ 0.5 and 5 ppm. The exact position in this range depends on several factors, including sample concentration, hydrogen bonding, and the type of solvent used. Since amine protons undergo fast proton exchange in solution, the protons are labile and therefore do not participate in any splitting with adjacent protons. Thus, the observed peak is...
11.1K
NMR Spectroscopy of Aromatic Compounds01:14

NMR Spectroscopy of Aromatic Compounds

6.3K
Aromatic compounds can be identified or analyzed using proton NMR and carbon‐13 NMR. Typically, aromatic hydrogens or hydrogens directly bonded to the aromatic rings are strongly deshielded by the aromatic ring current. Therefore, they absorb in the range of 6.5–8.0 ppm in proton NMR spectra. For instance, aromatic hydrogens directly bonded to the benzene ring absorb at 7.3 ppm. However, aromatic hydrogens of larger rings absorb farther upfield or downfield than the ideal range.
6.3K
NMR Spectroscopy of Benzene Derivatives01:34

NMR Spectroscopy of Benzene Derivatives

11.2K
Simple unsubstituted benzene has six aromatic protons, all chemically equivalent. Therefore, benzene exhibits only a singlet peak at δ 7.3 ppm in the 1H NMR spectrum. The observed shift is far downfield because the aromatic ring current strongly deshields the protons. Any substitution on the benzene ring makes the aromatic protons nonequivalent, and the protons split each other. The peak is, therefore, no longer a singlet and the splitting pattern and their associated coupling...
11.2K
NMR Spectroscopy: Chemical Shift Overview01:15

NMR Spectroscopy: Chemical Shift Overview

3.3K
The position of the absorption signal of a sample is reported relative to the position of the signal of tetramethylsilane (TMS), which is added as an internal reference while recording spectra. The difference between the absorption frequencies of the sample and TMS (in Hz) is divided by the spectrometer operating frequency (in MHz) to obtain a dimensionless quantity called the chemical shift. It is reported on the δ (delta) scale and expressed in parts per million.
For instance, the proton...
3.3K
NMR Spectroscopy: Spin–Spin Coupling01:08

NMR Spectroscopy: Spin–Spin Coupling

3.2K
The spin state of an NMR-active nucleus can have a slight effect on its immediate electronic environment. This effect propagates through the intervening bonds and affects the electronic environments of NMR-active nuclei up to three bonds away; occasionally, even farther. This phenomenon is called spin–spin coupling or J-coupling. Coupling interactions are mutual and result in small changes in the absorption frequencies of both nuclei involved. While nuclei of the same element are involved...
3.2K
NMR and Mass Spectroscopy of Carboxylic Acids01:30

NMR and Mass Spectroscopy of Carboxylic Acids

5.3K
In ¹H NMR spectroscopy, acidic protons (–COOH) of carboxylic acids are highly deshielded and absorb far downfield, at around 9–12 ppm. The chemical shift value depends on the concentration and solvent used.
While α protons of carboxylic acids absorb at 2–2.5 ppm, β protons absorb further upfield.
Carboxylic acids are easily identified by dissolving them in deuterium oxide, which results in a rapid exchange of the acidic protons with deuterium. This leads to the...
5.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diffusion-weighted magnetic resonance spectroscopy with selective refocusing.

Magma (New York, N.Y.)·2025
Same author

A Magnetic Resonance Study of Temperature Responsive Volume Phase Transition in a Hydrogel and Its Concurrent Release of Drug Carrier Molecules.

Magnetic resonance in chemistry : MRC·2025
Same author

Multidimensional dynamic NMR correlations in sedimentary rock cores at different liquid saturations.

Journal of magnetic resonance (San Diego, Calif. : 1997)·2021
Same author

A fluid specific dimension of confinement as a measure of wettability in porous media.

Journal of magnetic resonance (San Diego, Calif. : 1997)·2019
Same author

Characterising oil and water in porous media using correlations between internal magnetic gradient and transverse relaxation time.

Journal of magnetic resonance (San Diego, Calif. : 1997)·2019
Same author

Investigating pore geometry in heterogeneous porous samples using spatially resolved G<sub>0</sub>-Δχ<sub>app</sub> and G<sub>0</sub>-Δν correlations.

Journal of magnetic resonance (San Diego, Calif. : 1997)·2019

Related Experiment Video

Updated: Feb 5, 2026

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
10:10

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Published on: August 15, 2016

10.7K

Investigating structure-dependent diffusion in hydrogels using spatially resolved NMR spectroscopy.

Malgorzata Anna Wisniewska1, John Georg Seland1

  • 1Department of Chemistry, University of Bergen, Bergen 5007, Norway.

Journal of Colloid and Interface Science
|September 9, 2018
PubMed
Summary
This summary is machine-generated.

A new NMR method accurately measures surfactant diffusion in hydrogels for controlled drug delivery. This technique reveals how surfactant concentration affects transport, crucial for optimizing drug loading and release profiles.

Keywords:
1D chemical shift imagingDiffusionDrug deliverySlice selection NMR

More Related Videos

Author Spotlight: Exploring Intrinsically Disordered Protein Dynamics Through NMR Relaxation Experiments
09:25

Author Spotlight: Exploring Intrinsically Disordered Protein Dynamics Through NMR Relaxation Experiments

Published on: November 1, 2024

2.8K
Angle-resolved Photoemission Spectroscopy At Ultra-low Temperatures
08:53

Angle-resolved Photoemission Spectroscopy At Ultra-low Temperatures

Published on: October 9, 2012

18.2K

Related Experiment Videos

Last Updated: Feb 5, 2026

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
10:10

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Published on: August 15, 2016

10.7K
Author Spotlight: Exploring Intrinsically Disordered Protein Dynamics Through NMR Relaxation Experiments
09:25

Author Spotlight: Exploring Intrinsically Disordered Protein Dynamics Through NMR Relaxation Experiments

Published on: November 1, 2024

2.8K
Angle-resolved Photoemission Spectroscopy At Ultra-low Temperatures
08:53

Angle-resolved Photoemission Spectroscopy At Ultra-low Temperatures

Published on: October 9, 2012

18.2K

Area of Science:

  • Materials Science
  • Chemical Engineering
  • Biomedical Engineering

Background:

  • Polymer hydrogels incorporating drug-loaded surfactant micelles are vital for controlled drug delivery.
  • Understanding diffusion dynamics is key to optimizing drug loading and release kinetics.
  • Characterizing transport phenomena in these complex systems is essential for effective formulation.

Purpose of the Study:

  • To develop and validate a novel NMR protocol for investigating surfactant transport in hydrogels.
  • To quantify self- and mutual-diffusion coefficients of surfactants under non-equilibrium conditions.
  • To correlate diffusion behavior with hydrogel structure and surfactant concentration.

Main Methods:

  • Utilized a combination of 1D 1H NMR chemical shift imaging and slice-selective diffusion experiments.
  • Investigated micro- and macroscale transport of surfactant molecules within hydrogel matrices.
  • Determined diffusion coefficients within a short timeframe under non-equilibrium conditions.

Main Results:

  • Surfactant self-diffusion coefficient in hydrogel (Dsgel) decreased with concentration, plateauing at 6.6±0.5×10-11m2s-1.
  • Surfactant self-diffusion in solution (Dssln) remained constant at 6.7±0.3×10-11m2s-1.
  • Mutual diffusion coefficient (Dm) in the hydrogel system was measured at 7.7±0.5×10-11m2s-1.
  • Localized diffusion data correlated with chemical shift images, revealing structure-dependent behavior.

Conclusions:

  • The developed NMR protocol efficiently characterizes surfactant diffusion in hydrogels.
  • Results provide insights into structure-diffusion relationships critical for drug delivery systems.
  • This method is valuable for studying concentration-dependent structures and interfacial phenomena.