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Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
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Mean platelet volume and long-term cardiovascular outcomes in patients with stable coronary artery disease

Hideki Wada1, Tomotaka Dohi2, Katsumi Miyauchi2

  • 1Department of Cardiology, Juntendo University Shizuoka Hospital, Izunokuni, Shizuoka, Japan.

Atherosclerosis
|September 9, 2018
PubMed

Insights

Low mean platelet volume (MPV) is linked to worse outcomes in stable coronary artery disease (CAD) patients undergoing percutaneous coronary intervention (PCI). This finding contrasts with acute coronary syndrome (ACS) studies, highlighting MPV as a potential risk marker in stable CAD.

Area of Science:

  • Cardiology
  • Hematology
  • Clinical Research

Background:

  • Elevated mean platelet volume (MPV) is linked to adverse outcomes in acute coronary syndrome (ACS).
  • The prognostic value of MPV in stable coronary artery disease (CAD) remains unclear.
  • Investigating pre-procedural MPV in patients undergoing elective percutaneous coronary intervention (PCI) is crucial.

Purpose of the Study:

  • To determine the association between pre-procedural MPV levels and long-term outcomes in stable CAD patients.
  • To evaluate the risk of major adverse cardiac events (MACE) based on MPV quartiles.
  • To assess MPV as a continuous variable predictor of MACE.

Main Methods:

  • Retrospective analysis of 2872 stable CAD patients undergoing their first PCI.
  • Classification of patients into quartiles based on pre-procedural MPV.
  • Evaluation of MACE incidence (all-cause death, non-fatal myocardial infarction) over a median follow-up of 5.6 years.

Main Results:

  • The lowest MPV quartile showed a significantly higher MACE incidence (p < 0.01).
  • Low MPV (lowest quartile) was associated with a 43% increased risk of MACE after multivariable adjustment (HR: 1.43, p=0.009).
  • Decreasing MPV as a continuous variable independently predicted MACE (HR: 1.16 per µL decrease, p=0.007).

Conclusions:

  • Low MPV is associated with worse long-term clinical outcomes in stable CAD patients undergoing elective PCI.
  • This finding contrasts with previous research in ACS patients.
  • Pre-procedural MPV may serve as a valuable prognostic biomarker in stable CAD.
Abstract

Keywords:
Coronary artery diseaseMean platelet volumePercutaneous coronary intervention

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