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Updated: Feb 5, 2026

Making Conjugation-induced Fluorescent PEGylated Virus-like Particles by Dibromomaleimide-disulfide Chemistry
Published on: May 27, 2018
Disulfide-based PEGylated prodrugs: Reconversion kinetics, self-assembly and antitumor efficacy
Zichen Xie1, Jianfeng Song1, Heng Zhang1
1Emergency Department, Minhang Hospital, Fudan University, 39 Xinling Road, 201100, Shanghai, PR China.
Abstract:
The prodrug strategy serves well in drug formulation and delivery. Two disulfide-based PEGylated prodrugs were developed and the drug reconversion upon different conditions were studied in detail. The reconversion-induced oversaturation phenomenon was firstly reported here. We found the prodrug can co-assemble with parent drug via π-π stacking into well-defined nanoparticles. The PEG layer of the self-assembled nanoparticles improved the stability of the PEGylated prodrug by reducing the contact with biological enzymes. The nanoparticles also show favorable antitumor efficacy, both in vitro and in vivo.
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