Related Experiment Video

Updated: Feb 5, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

11.1K

Efficacy and safety of monoclonal antibody therapies for relapsing remitting multiple sclerosis: A network

Xinghua Xu1, Sumin Chi2, Qun Wang1

  • 1Department of Neurosurgery, Chinese PLA General Hospital, 28th Fuxing Road, Beijing 100853, China; National Clinical Research Center for Aging and Medicine, Chinese PLA General Hospital, Beijing, China.

Multiple Sclerosis and Related Disorders
|September 9, 2018
PubMed
Abstract

Insights

Monoclonal antibodies significantly reduce relapses in relapsing remitting multiple sclerosis (RRMS). Natalizumab plus interferon beta-1a and alemtuzumab offer the best balance of efficacy and safety for RRMS treatment.

Area of Science:

  • Neurology
  • Immunology
  • Pharmacology

Background:

  • Several monoclonal antibodies are approved for relapsing remitting multiple sclerosis (RRMS).
  • Lack of head-to-head trials makes treatment selection challenging.
  • This study compares the efficacy and safety of available monoclonal antibody therapies for RRMS.

Purpose of the Study:

  • To conduct a network meta-analysis comparing monoclonal antibodies for RRMS.
  • To evaluate relative efficacy and safety against placebo and interferon beta-1a.
  • To provide evidence-based guidance for RRMS treatment selection.

Main Methods:

  • Systematic search of PubMed, Embase, and Cochrane Library for RCTs.
  • Network meta-analysis of 14 studies involving 9412 patients.
  • Primary outcomes: annualized relapse rate and serious adverse events.

Main Results:

  • All monoclonal antibodies reduced annualized relapse rate compared to interferon beta-1a (45.3% ARR).
  • Natalizumab plus INFβ-1a and alemtuzumab showed high efficacy and safety.
  • Natalizumab and daclizumab had high efficacy but higher adverse event risks; ocrelizumab had high safety but lower efficacy.

Conclusions:

  • Network meta-analysis offers a comprehensive RRMS treatment comparison.
  • Natalizumab plus INFβ-1a and alemtuzumab are promising options.
  • Further direct comparison studies are needed for definitive guidance.
Keywords:
AlemtuzumabDaclizumabMonoclonal antibodyMultiple sclerosisNatalizumabOcrelizumab

More Related Videos

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

12.0K
Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia04:34

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia

Published on: February 17, 2023

1.6K

Related Concept Videos

Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.6K
Survey Safety01:28

Survey Safety

Surveying near highways, rough terrain, or power lines involves significant risks. Working along highways is particularly dangerous and requires the use of warning signs and flagmen. It is safest to avoid working directly on roads and use offsets whenever possible. When highway work is unavoidable, it must follow all safety guidelines. Surveyors should wear bright clothing, such as orange reflective vests, to ensure visibility to motorists, coworkers, and hunters. In construction zones, wearing...
410
Self-Efficacy01:29

Self-Efficacy

Self-efficacy is the belief in one's capacity to organize and execute actions necessary to manage prospective situations. This belief significantly influences how individuals approach goals, tasks, and challenges across different domains of life.Psychological and Educational ImpactsIndividuals with strong self-efficacy are more resilient in the face of difficulties. They are more likely to adopt effective problem-solving strategies, persist through obstacles, and regulate emotions such as...
230
Directing Effect of Substituents: meta-Directing Groups01:09

Directing Effect of Substituents: meta-Directing Groups

Substituents on the benzene ring that direct an incoming electrophile to undergo substitution at the meta position are called meta directors. All meta directors either have a positive charge on the atom directly bonded to the ring or a partial positive charge. These groups function by withdrawing electrons from the ring through inductive and resonance effects. Consider the carbocation intermediates formed upon the addition of an electrophile on nitrobenzene at the...
6.0K
Network Covalent Solids02:18

Network Covalent Solids

Network covalent solids contain a three-dimensional network of covalently bonded atoms as found in the crystal structures of nonmetals like diamond, graphite, silicon, and some covalent compounds, such as silicon dioxide (sand) and silicon carbide (carborundum, the abrasive on sandpaper). Many minerals have networks of covalent bonds.
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
16.2K
Household Wiring And Electrical Safety01:13

Household Wiring And Electrical Safety

Companies that supply power to most modern households use three conductors, typically called a three-wire line. While one is neutral, the other two are both at 120 V but with opposite polarity, giving a voltage of 240 V between them. With a three-wire line, high-power appliances that require 240 V, such as electric stoves and clothes dryers, are linked between the two hot lines. 120 V appliances can be connected between the neutral and either of the hot lines. The neutral side, which is always...
1.7K