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Related Experiment Video

Updated: Feb 5, 2026

Author Spotlight: Enhancing Understanding and Treatment Strategies with the NEC-on-a-Chip Model
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Surgical considerations for neonates with necrotizing enterocolitis.

Charles R Hong1, Sam M Han1, Tom Jaksic1

  • 1Center for Advanced Intestinal Rehabilitation, Department of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.

Seminars in Fetal & Neonatal Medicine
|September 10, 2018
PubMed
Summary

Necrotizing enterocolitis (NEC) is a severe intestinal disease in premature infants, often requiring surgery. Early surgical consultation and intervention are critical for improving outcomes in these vulnerable newborns.

Keywords:
LaparotomyNecrotizing enterocolitisNeonatal intensive care unitNeurodevelopmentPeritoneal drainagePrematurityShort bowel syndrome

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Area of Science:

  • Neonatal surgery
  • Pediatric gastroenterology
  • Critical care medicine

Background:

  • Necrotizing enterocolitis (NEC) is a serious intestinal condition primarily affecting premature and low birth weight infants.
  • Approximately 50% of NEC cases necessitate acute surgical intervention, highlighting the condition's severity.

Purpose of the Study:

  • To review the indications for surgical intervention in NEC.
  • To discuss the optimal surgical approaches for NEC.
  • To outline the risks and long-term complications associated with surgical NEC.

Main Methods:

  • This abstract is based on a review of current literature and clinical guidelines regarding surgical Necrotizing enterocolitis.
  • It synthesizes information on diagnostic indicators, surgical decision-making, and patient outcomes.

Main Results:

  • Early surgical consultation is recommended for NEC, with clear indications including medical therapy failure or pneumoperitoneum.
  • No definitive consensus exists on the best surgical approach (peritoneal drainage vs. laparotomy), with choices individualized based on patient factors and resources.
  • Surgical NEC is associated with significant risks of morbidity, mortality, and long-term complications like short bowel syndrome and neurodevelopmental impairment.

Conclusions:

  • Prompt surgical evaluation and intervention are crucial for infants with NEC.
  • Individualized surgical strategies are necessary, considering the infant's condition and available resources.
  • Further research is essential to optimize both short-term and long-term outcomes for neonates undergoing surgery for NEC.