Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aging01:26

Aging

713
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
713
Gene Therapy00:59

Gene Therapy

27.6K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.6K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.6K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.6K
Group Therapy01:26

Group Therapy

450
Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
450
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

3.6K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
3.6K
Cancer Therapies02:49

Cancer Therapies

10.2K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Brain-rejuvenating factor TIMP2 is associated with brain health and neuroprotective lifestyle in aged subjects.

medRxiv : the preprint server for health sciences·2026
Same author

Basic Science and Pathogenesis.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Youth-associated protein TIMP2 alters microglial state and function in the context of aging.

bioRxiv : the preprint server for biology·2025
Same author

Identification of Meibomian gland stem cell populations and mechanisms of aging.

Nature communications·2025
Same author

APOE genotype and brain amyloid are associated with changes in the plasma proteome in elderly subjects without dementia.

Annals of clinical and translational neurology·2024
Same author

Identification of Meibomian gland stem cell populations and mechanisms of aging.

bioRxiv : the preprint server for biology·2024

Related Experiment Video

Updated: Feb 5, 2026

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging
09:10

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging

Published on: January 30, 2026

164

Blood-Based Therapies to Combat Aging.

Joseph M Castellano

    Gerontology
    |September 10, 2018
    PubMed
    Summary

    Aging drives disease and healthcare costs, particularly neurological disorders. Blood-based therapies show promise for reversing aging aspects, but require further research into common molecular pathways for effective treatments.

    Area of Science:

    • Gerontology and Regenerative Medicine
    • Neuroscience and Aging
    • Molecular and Cellular Biology

    Background:

    • Aging is a primary risk factor for numerous diseases, including neurodegenerative conditions like Alzheimer's disease.
    • The global population is aging, leading to escalating healthcare costs associated with age-related ailments.
    • Current treatments for many age-associated diseases are limited, highlighting the need for novel therapeutic strategies.

    Purpose of the Study:

    • To review the current landscape of blood-based approaches for targeting aging processes.
    • To explore the potential of circulating blood molecules to reverse or mitigate age-related decline.
    • To identify challenges and propose future research directions for blood-derived therapeutics.

    Main Methods:

    Keywords:
    AgingAlzheimer’s diseaseGDF11Neurodegenerative diseaseOsteocalcinParabiosisTIMP2Young bloodYoung plasma

    More Related Videos

    Regenerative Therapy by Suprachoroidal Cell Autograft in Dry Age-related Macular Degeneration: Preliminary In Vivo Report
    10:24

    Regenerative Therapy by Suprachoroidal Cell Autograft in Dry Age-related Macular Degeneration: Preliminary In Vivo Report

    Published on: February 12, 2018

    10.8K
    Development of an Innovative LED-based Illumination Device for In Vitro Application of Photodynamic Therapy with Rose Bengal
    07:24

    Development of an Innovative LED-based Illumination Device for In Vitro Application of Photodynamic Therapy with Rose Bengal

    Published on: September 12, 2025

    524

    Related Experiment Videos

    Last Updated: Feb 5, 2026

    Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging
    09:10

    Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging

    Published on: January 30, 2026

    164
    Regenerative Therapy by Suprachoroidal Cell Autograft in Dry Age-related Macular Degeneration: Preliminary In Vivo Report
    10:24

    Regenerative Therapy by Suprachoroidal Cell Autograft in Dry Age-related Macular Degeneration: Preliminary In Vivo Report

    Published on: February 12, 2018

    10.8K
    Development of an Innovative LED-based Illumination Device for In Vitro Application of Photodynamic Therapy with Rose Bengal
    07:24

    Development of an Innovative LED-based Illumination Device for In Vitro Application of Photodynamic Therapy with Rose Bengal

    Published on: September 12, 2025

    524
  • Literature review of emerging blood-based anti-aging strategies.
  • Analysis of molecular mechanisms underlying age-associated dysfunction.
  • Discussion of translational potential for therapeutic development.

    • Main Results:

    • Blood contains molecules that can influence aging across different organs.
    • Youth-associated blood factors offer a potential avenue for therapeutic intervention.
    • Despite potential, significant challenges remain in developing practical blood-based treatments.

    Conclusions:

    • Blood-based interventions represent a promising frontier in combating aging and its associated diseases.
    • Further mechanistic studies are crucial to identify common pathways for targeted drug development.
    • Overcoming current challenges could lead to novel therapeutics for age-related conditions, including neurological disorders.